HTR2A and schizophrenia

    150 sentences in 87 studies


  1. The objective of this study was to explore the correlation between DRD2, HTR2A, SLC6A4, CYP1A2, and ABCB1 polymorphisms and clozapine response in 100 patients with Treatment Resistant Schizophrenia. PMID:38540209
  2. Revealing receptor ligand interactions of atypical antipsychotic drugs and screening anti schizophrenia ingredients in Magnolia officinalis based on 5 HTR2A SNAP Tag/CMC and DRD2 SNAP Tag/CMC models. PMID:38442497
  3. Our significant polymorphism findings, mainly those in DRD2 (rs1800497, rs1799978, and rs2734841), HTR2C (rs3813929), and HTR2A (rs6311), were largely consistent with earlier findings (predictors of RIS effectiveness in adult schizophrenia patients), confirming their validity for identifying ASD children with a greater likelihood of core symptom improvement compared to noncarriers/wild types. PMID:38421437
  4. Associations of rs6265 in BDNF, rs1800955 in DRD4, and rs6313 in HTR2A with schizophrenia in patients from the schizophrenia group separately compared to the control group were also found. PMID:38397229
  5. The most consistent and replicated result was reported for: 1) 5 HTR2A T102C, associated with SB in patients with schizophrenia (OR = 1.73 (1.11 2.69)) and 2) BDNF Val66Met (rs6265), with the Met Val + Val Val carriers found to be at risk for suicide in the Caucasian population (OR: 1.96 (1.58 2.43)), while Val Val vs. Val Met + Met carriers found to be at risk for suicide in the Asian populations (OR: 1.36 (1.04 1.78)). PMID:38315076
  6. Prognostic and immunomodulatory roles of schizophrenia associated genes HTR2A, COMT, and PRODH in pan cancer analysis and glioma survival prediction model. PMID:37564635
  7. A diagnosis of schizophrenia and the DRD2 rs1799732, DRD3 rs6280, and HTR2A rs7997012 genotypes can predict high treatment resistance to SGAs. PMID:37509727
  8. This study aimed to investigate the association between schizophrenia and two SNPs from one haplotype block, which lies in the 5 hydroxytryptamine receptor 2 A (5 HTR2A) gene in the Iranian population. PMID:36639522
  9. [Association of gene polymorphisms DRD3 rs6280, COMT rs4680 and HTR2A rs7322347 with schizophrenia]. PMID:35904302
  10. To check the association of genetic polymorphisms rs6280 of the DRD3 gene, rs4680 of the COMT gene, rs7322347 of the HTR2A gene with schizophrenia. PMID:35904302
  11. Analysis of publicly available post mortem gene expression data revealed that both EGR3 and HTR2A mRNA are reduced in the prefrontal cortex of schizophrenia patients compared to controls. PMID:35001075
  12. Association of 5 HTR2A T102C and A 1438G polymorphisms with clinical response to atypical antipsychotic treatment in schizophrenia: A meta analysis. PMID:34919991
  13. Associations of serotonin 2A receptor (5 HTR2A) gene polymorphisms with clinical response to atypical antipsychotics (AAPs) treatment in schizophrenia (SCZ) were inconsistent. PMID:34919991
  14. The association with schizophrenia was found for DRD3 rs6280 (p = 0.05) and HTR2A rs7322347 (p = 0.0013). PMID:34025476
  15. The present study investigated the association of nine polymorphisms in the four 5 hydroxytryptamine receptor (HTR) genes HTR1A, HTR2A, HTR3A, and HTR2C and the gene encoding for the serotonin transporter SLC6A4 with MetS in patients with schizophrenia. PMID:33807811
  16. The aim of the study was to characterize the pattern of transcript isoforms of HTR2A exon II in lymphocytes of the blood as peripheral biomarkers of schizophrenia development and the effectiveness of antipsychotic therapy. PMID:33409390
  17. In summary, our results suggest that levels of HTR2A exon II transcript isoforms are upregulated in patients with schizophrenia, but at the same time, elevated expression level of the studied HTR2A transcripts is associated with fewer side effects of the therapy. PMID:33409390
  18. Although these variants and genes were all implicated in schizophrenia in research studies, only two polymorphisms (HTR2A rs6311 and TCF4 rs9960767) were also reported to be associated with schizophrenia at a meta analytic or genome wide level of evidence. PMID:33324248
  19. Moreover, mitogen activated protein kinase 3 (MAPK3), calcium voltage gated channel subunit alpha1 C (CACNA1C), solute carrier family 6 member 4 (SLC6A4) and 5 hydroxytryptamine receptor 2A (HTR2A) genes are the most central genes in the pathogenesis of schizophrenia. PMID:32853652
  20. Association study between HTR2A rs6313 polymorphism and early response to risperidone and olanzapine in schizophrenia patients. PMID:32462699
  21. A set of 29 SNPs of genes of serotonin receptors HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR3B, and HTR6 was studied in a population of 449 Caucasians (226 females and 223 males) with verified clinical diagnosis of schizophrenia (according to ICD 10: F20). PMID:32390801
  22. HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol Treated Patients with Schizophrenia. PMID:32231051
  23. This study aimed to examine molecular associations of HTR1A, HTR1B, HTR2A, HTR2C and HTR6 gene polymorphisms with acute EPS in 229 male schizophrenia patients, following two weeks of haloperidol monotherapy. PMID:32231051
  24. Here we perform a case control study to explore a potential association between schizophrenia and variants within the antipsychotic drug molecular targets (DRD1, DRD2, DRD3, HTR2A, HTR6) and metabolizing enzymes (CYP2D6, COMT) genes in Armenian population including also analysis of their possible relationship with disease clinical symptoms. PMID:32086104
  25. 5 HTR2A (T102C), 5 HTTLPR, BDNF (Val66Met) polymorphisms previously reported to modify schizophrenia course are also associated with premorbid personality in schizophrenic patients. PMID:31089096
  26. COMT, 5 HTR2A, and SLC6A4 mRNA Expressions in First Episode Antipsychotic Naïve Schizophrenia and Association With Treatment Outcomes. PMID:30483162
  27. In this longitudinal study, we aim to investigate the expressions of Catechol O methyltransferase (COMT), serotonin 2A receptor (5 HTR2A), and serotonin transporter gene (SLC6A4) mRNA in first episode antipsychotic naïve schizophrenia and to test if these mRNA expressions are associated with cognitive deficits and treatment outcomes or not. PMID:30483162
  28. Method: We measured COMT, 5 HTR2A, and SLC6A4 mRNA expressions in 45 drug naive first episode schizophrenia patients and 38 health controls at baseline, and repeated mRNA measurements in all patients at the 8 week follow up. PMID:30483162
  29. Conclusion: Our findings suggest that dysregulated COMT and SLC6A4 mRNA expressions may implicate in the pathophysiology of schizophrenia, and that COMT and 5 HTR2A mRNA may be potential biomarkers to predict antipsychotic response. PMID:30483162
  30. Dopamine (DRD2) and Serotonin (HTR2A, 2C) Receptor Gene Polymorphisms do not influence early response to Risperidone in South Indian Patients with Schizophrenia. PMID:30332506
  31. To explore further, the present study aimed to assess the influence of DRD2 141 C Ins/Del, Taq1A and HTR2A 1438 G/A, 102T/C and HTR2C 759 C/T genetic polymorphisms in response to risperidone in patients with schizophrenia. PMID:30332506
  32. The promoter polymorphisms in HTR2A gene associated with schizophrenia in Chinese of Han ethnicity. PMID:29198573
  33. Serotonin receptor 2A (HTR2A) is an important signalling factor implicated in cognitive functions and known to be associated with schizophrenia. PMID:28054990
  34. The biological significance of HTR2A in schizophrenia remains unclear as molecular analyses including genetic association, mRNA expression and methylation studies have reported inconsistent results. PMID:28054990
  35. In this study, we examine HTR2A expression and methylation and the interaction with HTR2A polymorphisms to identify their biological significance in schizophrenia. PMID:28054990
  36. HTR2A mRNA levels were reduced by 14% (p = 0.006) in schizophrenia compared to controls. PMID:28054990
  37. Three CpG sites were hypermethylated in schizophrenia (cg5 p = 0.028, cg7 p = 0.021, cg10 p = 0.017) and HTR2A polymorphisms rs6314 (p = 0.008) and rs6313 (p = 0.026) showed genetic association with schizophrenia. PMID:28054990
  38. Differential HTR2A expression in schizophrenia in our study may be the result of the combined effect of multiple differentially methylated CpG sites. PMID:28054990
  39. Epigenetic HTR2A regulation may alter brain function, which contributes to the development of schizophrenia. PMID:28054990
  40. We describe the association between HPRL and a set of 29 SNPs from 5 HT receptor genes HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR3B and HTR6 in a population of 446 Caucasians (221 males/225 females) with a clinical diagnosis of schizophrenia (according to ICD 10: F20) who were treated with classical and/or atypical antipsychotic drugs. PMID:27654063
  41. Interaction between Methylation and CpG Single Nucleotide Polymorphisms in the HTR2A Gene: Association Analysis with Suicide Attempt in Schizophrenia. PMID:26812280
  42. Furthermore, direct methylation analysis was performed using genomic DNA from peripheral leukocytes employing bisulfite pyrosequencing to assess the contributions of six CpG sites in HTR2A exon I in 67 schizophrenia patients assessed for lifetime suicide attempt. PMID:26812280
  43. An insight into the understanding of 5 HTR2A variants leading to schizophrenia. PMID:25758569
  44. The primary outcome assessed change from baseline in the Positive and Negative Syndrome Scale (PANSS) total score in an overall schizophrenia population and a predefined subpopulation which excluded non Hispanic white patients with the A/A genotype at the HTR2A SNP rs7330461. PMID:25539791
  45. Association of schizophrenia with T102C (rs6313) and 1438 A/G (rs6311) polymorphisms of HTR2A gene. PMID:25287874
  46. We found no significant association between schizophrenia and genotypic or allele frequencies of HTR2A gene 102T/C (rs6313) and 1438 A/G (6311) polymorphisms. PMID:25287874
  47. However, comparison of HTR2A gene 102 T/C and 1438 A/G polymorphisms in terms of genotypic and allele frequencies between the two patient groups, with or without a family history of schizophrenia, shows that T and A allele frequencies were significantly higher (p < 0.05) in the case group that has a history of schizophrenia in their family. PMID:25287874
  48. Ongoing research has identified a region of the HTR2A promoter that has been associated with a number of medical outcomes in adults and infants, including bipolar disorder, schizophrenia, chronic fatigue syndrome, borderline personality disorder, suicidality, and neurobehavioral outcomes. PMID:25043477
  49. HTR2A and HTR2A gene variations are implicated in depression, schizophrenia, anxiety and obsessive compulsive disorder. PMID:25041420
  50. Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia. PMID:24962835
  51. A number of studies have assessed a relationship between the T102C polymorphism in the HTR2A gene with an increased risk of major depressive disorder (MDD), bipolar disorder (BPD), and schizophrenia (SCZ). PMID:24962835
  52. Finally, levels of HTR2A were lower in the CNS of rats treated with imipramine, but not fluoxetine, for 28 d, but not 10 d. From our current and previous data we conclude cortical HTR2A are lower in schizophrenia, MDD, people with mood disorders who died by suicide, rats treated with some antipsychotic or some antidepressant drugs. PMID:24495390
  53. Several lines of evidence have indicated that serotonin 2A receptor (HTR2A) may be involved in the pathophysiology of schizophrenia. PMID:23857788
  54. The purpose of this study was to evaluate the association between HTR2A T02C polymorphism and schizophrenia in a Chinese Han population. PMID:23857788
  55. Our results suggest that the HTR2A T102C polymorphism may confer susceptibility to schizophrenia in Han Chinese. PMID:23857788
  56. Our results suggest that HTR2A rs6314 affects 5 HT2AR expression and functionally contributes to genetic modulation of known endophenotypes of schizophrenia like higher level cognitive behaviors and related prefrontal activity, as well as response to treatment with olanzapine. PMID:23842608
  57. HTR2A 1438A/G polymorphism influences the risk of schizophrenia but not bipolar disorder or major depressive disorder: a meta analysis. PMID:23404241
  58. The incidence of psychiatric disorders has been shown to have a strong genetic component, and we conducted this study to investigate whether the 1438A/G polymorphism of the HTR2A gene was associated with susceptibility to schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). PMID:23404241
  59. [An association study of polymorphisms in HTR2A, BDNF and SLC6A4 genes with paranoid schizophrenia and suicidal behavior]. PMID:23250597
  60. Using this biochip, allele and genotype frequencies for the polymorphisms of HTR2A, BDNF and SLC6A4 genes in 198 patients with schizophrenia and 192 healthy individuals have been obtained. PMID:23250597
  61. The allele T of the HTR2A polymorphism rs6314 was identified as protective against the development of paranoid schizophrenia (p=0,014). PMID:23250597
  62. The results confirm the hypothesis that the HTR2A plays an important role in the etiology of schizophrenia and suicidal behavior. PMID:23250597
  63. Analysis of two chromosome 13 schizophrenia candidate genes, D amino acid oxidase activator (DAOA) and 5 hydroxytryptamine (serotonin) receptor 2A (5 HTR2A), failed to identify non synonymous coding mutations but did identify homozygous risk polymorphisms. PMID:22214315
  64. Hypomethylation of the serotonin receptor type 2A Gene (HTR2A) at T102C polymorphic site in DNA derived from the saliva of patients with schizophrenia and bipolar disorder. PMID:21598376
  65. Several lines of evidence indicate that dysfunction of serotonin signaling and HTR2A receptor are involved in the pathogenesis of schizophrenia (SCZ) and bipolar disorder (BD). PMID:21598376
  66. Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder. PMID:21550210
  67. However, evidence for the role of HTR2A polymorphism(s) in schizophrenia (SCZ) and bipolar disorder (BD) has been elusive. PMID:21550210
  68. We aimed to investigate the associations of HTR1A C 1019G, HTR2A 1438A/G, TPH1 218A/C, and TPH2 703G/T variants with schizophrenia. PMID:21399903
  69. A total of 202 patients with schizophrenia and 165 normal controls were genotyped for HTR1A C 1019G, HTR2A 1438A/G, TPH1 218A/C, and TPH2 703G/T single nucleotide polymorphisms (SNPs). PMID:21399903
  70. Polymorphism of serotonin receptor genes (5 HTR2A) and Dysbindin (DTNBP1) and individual components of short term verbal memory processes in Schizophrenia. PMID:20683774
  71. Associations between polymorphisms in the T102C and A 1438G loci of the 5 HTR2A and the P1763 and P1578 markers of the DTNBP1 gene with the overall productivity and individual subprocesses of shortterm verbal memory were studied in 4 5 patients with schizophrenia and 290 healthy subjects. PMID:20683774
  72. Linkage of schizophrenia with TPH2 and 5 HTR2A gene polymorphisms in the Malay population. PMID:20623453
  73. We found a significant association of A1438G of 5 HTR2A with schizophrenia in Malays. PMID:20623453
  74. Forty nine patients, with schizophrenia or schizoaffective disorder and treated with clozapine (n = 22) or olanzapine (n = 27), were evaluated for fasting levels of C peptide, insulin and blood glucose, homeostasis model assessment index for insulin resistance (HOMA IR) and body mass index (BMI), and genotyped for the 1438A/G, 783A/G, 102T/C, and His452Tyr polymorphisms of the HTR2A gene. PMID:20521326
  75. Association analysis of GRM2 and HTR2A with methamphetamine induced psychosis and schizophrenia in the Japanese population. PMID:20211215
  76. Therefore, we conducted a case control study with Japanese samples (738 schizophrenia patients, 196 methamphetamine induced psychosis patients, and 802 controls) to evaluate the association and interaction between GRM2, HTR2A and schizophrenia. PMID:20211215
  77. We did not detect an association between GRM2 or HTR2A and schizophrenia. PMID:20211215
  78. In addition, no interactions of GRM2 and HTR2A were found in methamphetamine induced psychosis or schizophrenia. PMID:20211215
  79. The 102T/C single nucleotide polymorphism (SNP) in the 5 hydroxytryptamine receptor 2A (HTR2A) gene has been reported to be associated with schizophrenia. PMID:19855357
  80. However, SNPs of the HTR2A gene other than the 102T/C have attracted only limited studies in relation to schizophrenia, and also on the whole SNPs of the HTR2A gene have been little studied in relation to clinical parameters in patients. PMID:19855357
  81. Therefore, the aim of this study was to evaluate the impact of main functionally characterized SNPs of the HTR2A gene on both the schizophrenia and clinical parameters. PMID:19855357
  82. Ninety four patients with schizophrenia and 57 control subjects were genotyped for the 1438A/G, 783A/G, 102T/C and His452Tyr SNPs of the HTR2A gene. PMID:19855357
  83. The present findings bring further support to the view that the 1438A/G, 102T/C and His452Tyr polymorphisms of the HTR2A gene are connected with a constitutive cellular change that causes susceptibility to schizophrenia. PMID:19855357
  84. [Serotonin receptor (5 HTR2A) and dysbindin (DTNBP1) genes and component process variables of short term verbal memory in schizophrenia]. PMID:19672240
  85. An association study of variations in the DTNBP1 (P1763 and P1578) and 5 HTR2A (T102C and A 1438G) genes with short term verbal memory efficiency and its component process variables was carried out in 405 patients with schizophrenia and 290 healthy controls. PMID:19672240
  86. Overall, the data obtained are in line with the conception of DTNBP1 and 5 HTR2A involvement in different component process variables of memory in healthy subjects and patients with schizophrenia. PMID:19672240
  87. This study investigated whether the efficacy of aripiprazole can be predicted by functional HTR2A A 1438G/T102C polymorphisms (rs63311/rs6313) as modified by clinical factors in Han Chinese hospitalized patients with acutely exacerbated schizophrenia. PMID:19387614
  88. While further research into the molecular mechanisms underlying this interaction is needed, our results underscore the role of 5 HTR in PPI modulation and further implicate the 5 HTR1A G 1019C and the 5 HTR2A T102C polymorphisms in the pathophysiology of schizophrenia. PMID:19352591
  89. The impact of HTR2C and HTR2A polymorphisms on body mass index (BMI), glucose insulin homeostasis, and blood lipid levels was evaluated in 46 patients with schizophrenia or schizoaffective disorder and treated with olanzapine (n = 28) or clozapine (n = 18) for at least 6 months. PMID:19142110
  90. We conducted a pharmacogenetic study to evaluate whether variants in dopamine related genes (DRD1 DRD5, AKT1 and GSK3beta) and serotonin receptor genes (HTR1A, HTR1B, HTR1D, HTR2A, HTR2C, HTR6 and HTR7) can be used to predict the efficacy of risperidone treatment for schizophrenia. PMID:18855532
  91. Genetic variation in the serotonin 2A receptor (HTR2A) has been associated with both schizophrenia and suicidal behavior. PMID:18712714
  92. [Investigation of association of the brain derived neurotrophic factor (BDNF) and a serotonin receptor 2A (5 HTR2A) genes with voluntary and involuntary attention in schizophrenia]. PMID:18454098
  93. To investigate the effect of Val66Met BDNF and 5 HTR2A T102C polymorphisms on the characteristics of voluntary and involuntary visual attention, 89 patients with schizophrenia, 91 their well relatives and 163 controls have been studied. PMID:18454098
  94. Relationship between three serotonin receptor subtypes (HTR3A, HTR2A and HTR4) and treatment resistant schizophrenia in the Japanese population. PMID:18359159
  95. The authors carried out a genetic association study of 14 schizophrenia candidate genes (RGS4, DISC1, DTNBP1, STX7, TAAR6, PPP3CC, NRG1, DRD2, HTR2A, DAOA, AKT1, CHRNA7, COMT, and ARVCF). PMID:18198266
  96. Results in SNPs previously reported as associated with schizophrenia were consistent with chance expectation, and four functional polymorphisms in COMT, DRD2, and HTR2A did not produce nominally significant evidence to support previous evidence for association. PMID:18198266
  97. Could HTR2A T102C and DRD3 Ser9Gly predict clinical improvement in patients with acutely exacerbated schizophrenia? PMID:17924589
  98. This study seeks to replicate previous results indicating that T102C in the serotonin 2A receptor (HTR2A) and Ser9Gly in the dopamine D3 receptor (DRD3) were associated with a risperidone response to acutely exacerbated schizophrenia, and to determine whether possession of these alleles predicts clinical improvement in a naturalistic setting. PMID:17924589
  99. Variants at the gene encoding for the 5 hydrosytryptamine (serotonin) receptor 2A (HTR2A) have been associated with many psychiatric disorders such as schizophrenia, mood disorders, attention deficit hyperactivity disorder, suicide, anxiety disorders, obsessive compulsive disorder, eating disorders, and Alzheimer's disease. PMID:17691947
  100. The genotype and allele frequencies of HTR2A and CYP1A2 gene were similar in schizophrenia with TD, schizophrenia without TD, and healthy controls. PMID:17688403
  101. The results of the present study seem to indicate that HTR2A gene polymorphism influences the tendency to express TD following prolonged antipsychotic drug exposure in Turkish schizophrenia patients. PMID:17688403
  102. Indeed, association between schizophrenia and the T102C silent polymorphism of the 5 HTR2A gene has been reported. PMID:17617023
  103. We analysed the 5 HTR2A T102C and A 1438G polymorphisms in clinically stable schizophrenia patients (SPs) and healthy volunteers (HVs). PMID:17617023
  104. Evidence that HTR2A receptor gene may be subject to genomic imprinting prompted us to examine a collection of family trios for evidence of an association between the HTR2A T102C polymorphism and psychosis in schizophrenia or bipolar disorder. PMID:17407792
  105. There was no genetic association between HTR2A T102C with either schizophrenia or bipolar disorder under the assumption of a parent of origin effect, and these data together essentially exclude imprinting at this locus as a potential explanation for the complex inheritance observed in major psychoses. PMID:17407792
  106. Supportive evidence for the association between the T102C 5 HTR2A gene polymorphism and schizophrenia: a large scale case control and family based study. PMID:17240119
  107. Serotonin type 2A receptors (5 HTR2A) have long been implicated in schizophrenia pathology. PMID:17240119
  108. Molecular genetic studies revealed that the T102C polymorphism of the 5 HTR2A gene is associated with schizophrenia, with the CC genotype frequency being higher in patients compared to healthy controls. PMID:17240119
  109. In conclusion, our replication study provides further evidence for association between the 5 HTR2A receptor T102C polymorphism and schizophrenia. PMID:17240119
  110. Extensive linkage disequilibrium mapping at HTR2A and DRD3 for schizophrenia susceptibility genes in the Galician population. PMID:17125970
  111. We detected nominal significant association with schizophrenia for several haplotype tag SNPs (htSNPs) at HTR2A, although the significance was lost after multiple test corrections. PMID:17125970
  112. The 102T/C polymorphism of the serotonin 2A receptor (HTR2A) gene is reported to be associated with schizophrenia and other diseases and phenotypes. PMID:17069769
  113. Altered HTR2A expression has been found in relation to several neuropsychiatric conditions, including depression and schizophrenia. PMID:17069769
  114. We performed primer extension assays to measure relative expression of allele specific HTR2A transcripts in mRNAs isolated from the prefrontal cortex of 31 individuals with schizophrenia and from peripheral lymphocytes (PBLs) of 31 healthy individuals heterozygous for 102T/C. PMID:17069769
  115. We studied P300 parameters and the following polymorphisms: T102C for the serotonin receptor type 2A (5 HTR2A) gene, the 5 HTTLPR for the serotonin transporter gene, 809G/A, 616G/C N 52C/T SNPs in the promoter region of the dopamine D4 receptor (DRD4) gene and the Val158Met polymorphism of the catechol O methyltransferase (COMT) in 74 patients with schizophrenia and spectrum disorders and 71 their first degree relatives. PMID:16281377
  116. 5 HTR2A gene 1438G/A polymorphism was probably not associated with APS induced weight gain in Chinese Han patients with schizophrenia in this study. PMID:16215954
  117. Over the last decade the gene encoding 5 hydroxytryptamine (serotonin) receptor 2A (HTR2A) has been implicated as a functional candidate in many neuropsychiatric phenotypes including: schizophrenia, attention deficit hyperactivity disorder (ADHD), affective disorders, eating disorders, anxiety disorders, obsessive compulsive disorder, suicide and Alzheimer's disease (AD). PMID:16026119
  118. For example, several genes including those encoding dopamine receptors (DRD2, DRD3, and DRD4), serotonin receptor 2A (HTR2A) and catechol O methyltransferase (COMT) have been implicated in the etiology of schizophrenia and related disorders through meta analyses and large, multicenter studies. PMID:15952869
  119. The significant interaction effect between 5 HTTLPR and 5 HTR2A polymorphisms on the development of schizophrenia as well as on the antipsychotics response, family history, symptomatology and age at onset, was not found. PMID:15893580
  120. These results suggest that the interaction between 5 HTTLPR and 5 HTR2A polymorphisms may not contribute to susceptibility to schizophrenia as well as some clinical factors such as antipsychotic response, at least in the Korean population. PMID:15893580
  121. We detected 7 single nucleotide polymorphisms (SNPs) on 13q14, one (rs6313) present at the HTR2A locus and the other 6 at the KPNA3 locus, among 124 British family trios consisting of mother, father and affected offspring with schizophrenia. PMID:15882913
  122. Recent studies suggest that the 5 hydroxytryptamine receptor 2A (5 HT2A) gene (HTR2A) T102C and G 1438A polymorphisms may influence treatment response of risperidone or olanzapine for schizophrenia's negative symptoms (e.g., blunted affect and social withdrawal). PMID:15882132
  123. Meta analyses of pooled ORs support association of schizophrenia to the Ser311Cys polymorphism in DRD2 and the T102C polymorphism in HTR2A, and of attention deficit hyperactivity disorder to the 48 bp repeat in DRD4. PMID:15802092
  124. No association of the T102C polymorphism of the serotonin 2A receptor gene (HTR2A) with suicidality in schizophrenia. PMID:15469201
  125. The goal of the present study was to test the association of allele C of T102C HTR2A polymorphism with suicidality in patients with schizophrenia or schizoaffective disorder. PMID:15469201
  126. The results of this study did not demonstrate a robust association of the allele C of the T102C HTR2A polymorphism with lifetime or current suicidality in patients with schizophrenia. PMID:15469201
  127. Some evidence implicates methylation of the promoter regions of the DRD2 and HTR2A genes in schizophrenia and mood disorders as well. PMID:15108180
  128. In this study we examined the contribution of the T 102C and A 206G transitions in the 5 HTR2a and DRD3 receptor genes respectively to genetic susceptibility and phenotypic expression of schizophrenia disorder within the Greek population. PMID:15083167
  129. 102T/C SNP in the 5 hydroxytryptamine receptor 2A (HTR2A) gene and schizophrenia in two southern Han Chinese populations: lack of association. PMID:15048642
  130. Previous studies have shown an association between the T102C polymorphism of the 5 hydroxytryptamine receptor 2A (HTR2A) gene and schizophrenia. PMID:15048642
  131. These data did not provide evidence for a contribution of the 102T/C SNP of HTR2A gene to susceptibility to the southern Han Chinese schizophrenia. PMID:15048642
  132. Although the association of schizophrenia with the C allele of HTR2A was confirmed by a meta analysis 5 years ago, there was a continuous debate because negative findings were also considerable, which may have been due to ethnic differences in association. PMID:14741324
  133. The serotonin 2A (HTR2A) receptor is a molecule of particular interest in biological psychiatry, as it is an important target for psychotropic drugs, and altered HTR2A expression has been found in several neuropsychiatric conditions, including depression and schizophrenia. PMID:14699448
  134. Genetic association has been reported between a synonymous 102T/C polymorphism in the gene encoding HTR2A and a number of clinical phenotypes, including schizophrenia, clozapine response, psychotic symptoms in Alzheimer's disease and certain features of depression. PMID:14699448
  135. Serotonin receptor type 2 (5 HTR2A) polymorphism was consistently reported to be related to schizophrenia and some clinical presentations of the disease. PMID:14681967
  136. The present study aimed at searching for association between 5 HTR2A polymorphism and schizotypic personality traits being considered as recognized phenotype predisposing to schizophrenia. PMID:14681967
  137. [A 1438 G serotonin receptor type 2A (5 HTR2A) gene polymorphism in patients in patients with schizophrenia]. PMID:12830506
  138. A 1438 G 5 HTR2A gene polymorphism is known to be related to some clinical presentations of endogenous psychoses, in particular, of schizophrenia. PMID:12830506
  139. In the past, there have been many epidemiological and genetic studies of mood disorders, schizophrenia, and alcohol dependence, and in this study, the human serotonin 2A receptor (5 HTR2A) polymorphism was examined in 80 patients with mood disorders, 50 patients with schizophrenia and 41 patients with alcohol dependence. PMID:26983355
  140. The results suggest that 5 HTR2A (102T/C, 1438G/A) polymorphism might not be associated with susceptibility to schizophrenia or mood disorders, and it might not be a risk factor contributing to alcohol dependency. PMID:26983355
  141. [Polymorphism of the serotonin receptor (5 HTR2A) gene and verbal fluency in normalcy and schizophrenia]. PMID:12624948
  142. To study the effect of the serotonergic brain system on verbal fluency (i.e., the ability to rapidly extract necessary words from the vocabulary), the T102C polymorphism of the serotonin receptor type 2A (5 HTR2A) gene was tested for association with verbal fluency in 108 patients with schizophrenia or schizotypic disorders and 97 mentally healthy individuals. PMID:12624948
  143. The results did not support the association between the 5 HTR2A polymorphism and verbal fluency in normalcy, and agree with the assumed contribution of genotype A2A2 to the severity of schizophrenia. PMID:12624948
  144. Genetic polymorphism of the serotonin receptor (5 HTR2A) gene has been reported to be associated with the expression of clinical signs characteristic of major psychoses, including schizophrenia and affective disorders. PMID:11421130
  145. Lack of association between serotonin 2A receptor gene (HTR2A) polymorphisms and tardive dyskinesia in schizophrenia. PMID:11317228
  146. Three polymorphisms in HTR2A, one silent (C102T), one that alters the amino acid sequence (his452tyr) and one in the promoter region (A 1437G) were investigated in 136 patients refractory or intolerant to treatment with typical antipsychotics and with a DSM IIIR diagnosis of schizophrenia. PMID:11317228
  147. (2) We examined the association of three polymorphisms in the 5 HT2A receptor gene (HTR2A) with TD susceptibility T102C(3) and his452tyr(4) in the coding region and A 1438G(5) in the promoter in matched schizophrenia patients with (n = 59, SCZ TD Y) and without TD (n = 62, SCZ TD N) and normal control subjects (n = 96). PMID:11317227
  148. The putative role of epigenetic factors is shown by the epigenetic interpretation of genetic association studies of the genes for serotonin 2A (HTR2A) and the dopamine D3 (DRD3) receptors in schizophrenia. PMID:10869881
  149. A positive association between the serotonin 2A receptor gene (HTR2A) and schizophrenia was found, but not between schizophrenia and the serotonin 1A receptor gene. PMID:8678105
  150. The positive association we report here would suggest that the DNA region with susceptibility to schizophrenia lies in the HTR2A on the long arm of chromosomes 13. PMID:8678105