Most studied addiction related genes

These genes are ranked by the number of PubMed abstracts that contain the name of the gene and one or more addiction related keyword. Alias were obtained from NCBI gene database and have been curated to remove most, but not all, false matches.

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1. FOS (AP 1; C FOS; CFOS; FOS PROTO ONCOGENE, AP 1 TRANSCRIPTION FACTOR SUBUNIT)
   
2. BDNF (ANON2; BRAIN DERIVED NEUROTROPHIC FACTOR; BULN2)
   
3. TH (DYT14; DYT5B; TYROSINE HYDROXYLASE; TYROSINEHYDROXYLASE)
   
4. OPRM1 (LMOR; M OR 1; MOR1; OPIOID RECEPTOR MU 1; OPRM)
   
5. CNR1 (CNRS1; PROTOCADHERIN ALPHA CLUSTER, COMPLEX LOCUS)
   
6. DRD2 (D2DR; DOPAMINE RECEPTOR D2)
   
7. CREB1 (CAMP RESPONSIVE ELEMENT BINDING PROTEIN 1; CREB; CREB 1)
   
8. SLC6A4 (5 HTT; 5 HTTLPR; 5HTT; 5HTTLPR; HSERT; OCD1; SERT; SERT1; SOLUTE CARRIER FAMILY 6 MEMBER 4)
   
9. TNF (TNF ALPHA; TNFA; TNFALPHA; TNFSF2; TNLG1F; TUMOR NECROSIS FACTOR)
   
10. CYP2B6 (CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6; CYTOCHROME P450 FAMILY 2 SUBFAMILY B MEMBER 6; EFVM; IIB1; P450)
    
11. NPY (NEUROPEPTIDE Y; NEUROPEPTIDEY; PYY4)
    
12. GRM5 (GLUTAMATE METABOTROPIC RECEPTOR 5; GPRC1E; MGLU5; MGLUR5; PPP1R86)
    
13. GRIN2B (EIEE27; GLUN2B; GLUTAMATE IONOTROPIC RECEPTOR NMDA TYPE SUBUNIT 2B; HNR3; MRD6; NMDAR2B; NR2B)
    
14. HTR1A (5 HT 1A; 5 HT1A; 5 HYDROXYTRYPTAMINE RECEPTOR 1A; 5HT1A; 5HT1A; ADRB2RL1; ADRBRL1; PFMCD)
    
15. GRIA1 (GLUA1; GLUH1; GLUR1; GLURA; GLUTAMATE IONOTROPIC RECEPTOR AMPA TYPE SUBUNIT 1; HBGR1)
    
16. ALDH2 (ALDEHYDE DEHYDROGENASE 2 FAMILY MEMBER; ALDH E2; ALDHE2; ALDHI; ALDM)
    
17. HTR2A (5 HT2A; 5 HYDROXYTRYPTAMINE RECEPTOR 2A; 5HT2A; HTR2)
    
18. CRHR1 (CORTICOTROPIN RELEASING HORMONE RECEPTOR 1; CRF R; CRF R 1; CRF R1; CRF1; CRFR; CRFR 1; CRFR1; CRH R 1; CRH R1; CRHR; CRHR1L)
    
19. GRM2 (GLUR2; GLUTAMATE METABOTROPIC RECEPTOR 2; GPRC1B; MGLU2; MGLUR2)
    
20. CHRNA5 (CHOLINERGIC RECEPTOR NICOTINIC ALPHA 5 SUBUNIT; LNCR2)
    
21. IL6 (BSF 2; BSF2; IFN BETA 2; IFNB2; IL 6; INTERLEUKIN 6; INTERLEUKIN6)
    
22. COMT (CATECHOL O METHYLTRANSFERASE; HEL S 98N)
    
23. PDYN (ADCA; PENKB; PRODYNORPHIN; SCA23)
    
24. FAAH1 (FAAH 1; FATTY ACID AMIDE HYDROLASE; PSAB)
    
25. NPS (NEUROPEPTIDE S)
    
26. MAPK3 (ERK 1; ERK1; ERT2; HS44KDAP; HUMKER1A; MITOGEN ACTIVATED PROTEIN KINASE 3; P44 ERK1; P44 MAPK; P44ERK1; P44ERK1; P44MAPK; P44MAPK; PRKM3)
    
27. FOSB (AP 1; FOSB PROTO ONCOGENE, AP 1 TRANSCRIPTION FACTOR SUBUNIT; G0S3; GOS3; GOSB)
    
28. CRH (CORTICOTROPIN RELEASING HORMONE; CRH1)
    
29. TLR4 (ARMD10; CD284; TLR 4; TOLL LIKE RECEPTOR 4)
    
30. GRIA2 (GLUA2; GLUR 2; GLUR B; GLUR K2; GLUR2; GLUR2; GLURB; GLURB; GLURK2; GLUTAMATE IONOTROPIC RECEPTOR AMPA TYPE SUBUNIT 2; HBGR2)
    
31. CYP2A6 (CPA6; CYP2A; CYP2A3; CYPIIA6; CYTOCHROME P450 FAMILY 2 SUBFAMILY A MEMBER 6; P450C2A; P450PB)
    
32. HTR2C (5 HT1C; 5 HT2C; 5 HTR2C; 5 HYDROXYTRYPTAMINE RECEPTOR 2C; 5HT1C; 5HT2C; 5HTR2C; HTR1C)
    
33. ADH1B (ADH2; ALCOHOL DEHYDROGENASE 1B CLASS I , BETA POLYPEPTIDE; HEL S 117)
    
34. DRD4 (D4DR; DOPAMINE RECEPTOR D4)
    
35. ARC (ACTIVITY REGULATED CYTOSKELETON ASSOCIATED PROTEIN; ARG3.1; HARC)
    
36. MAOA (BRNRS; MAO A; MONOAMINE OXIDASE A)
    
37. CYP2E1 (CPE1; CYP2E; CYTOCHROME P450 FAMILY 2 SUBFAMILY E MEMBER 1; P450 J; P450C2E; P450J)
    
38. SLC1A2 (EAAT2; EIEE41; GLT 1; GLT1; HBGT; SOLUTE CARRIER FAMILY 1 MEMBER 2)
    
39. GRIN2A (EPND; FESD; GLUN2A; GLUTAMATE IONOTROPIC RECEPTOR NMDA TYPE SUBUNIT 2A; NMDAR2A; NR2A)
    
40. POMC (OBAIRH; PROOPIOMELANOCORTIN)
    
41. SLC6A3 (DAT1; PKDYS; PKDYS1; SOLUTE CARRIER FAMILY 6 MEMBER 3)
    
42. NGF (BETA NGF; BETANGF; HSAN5; NERVE GROWTH FACTOR; NGFB)
    
43. DBH (DOPAMINE BETA HYDROXYLASE; ORTHYP1)
    
44. PENK (PENK A; PENKA; PROENKEPHALIN)
    
45. HTR1B (5 HT 1B; 5 HT 1D BETA; 5 HT1B; 5 HT1DB; 5 HYDROXYTRYPTAMINE RECEPTOR 1B; 5HT1B; 5HT1DB; HTR1D2; HTR1DB)
    
46. JUN (AP 1; C JUN; CJUN; CJUN; JUN PROTO ONCOGENE, AP 1 TRANSCRIPTION FACTOR SUBUNIT)
    
47. CASP3 (CASPASE 3; CASPASE3; CPP32; CPP32B; SCA 1; SCA1)
    
48. CHRNA3 (BAIPRCK; CHOLINERGIC RECEPTOR NICOTINIC ALPHA 3 SUBUNIT; LNCR2; NACHRA3; PAOD2)
    
49. NEUROTENSIN (NMN 125; NMN125; NT/N; NTS1)
    
50. NTRK2 (EIEE58; GP145 TRKB; GP145TRKB; NEUROTROPHIC RECEPTOR TYROSINE KINASE 2; OBHD; TRK B; TRKB; TRKB)
    
51. CAMK2G (CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE II GAMMA; CAMK; CAMK II; CAMKG; CAMKII; MRD59)
    
52. TRPV1 (TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 1)
    
53. CYP2D6 (CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; CYTOCHROME P450 FAMILY 2 SUBFAMILY D MEMBER 6; P450 DB1; P450C2D; P450DB1)
    
54. CORT (CORTISTATIN; CST 14; CST 17; CST 29; CST14; CST17; CST29)
    
55. GFAP (ALXDRD; GLIAL FIBRILLARY ACIDIC PROTEIN)
    
56. GABRA2 (EIEE78; GAMMA AMINOBUTYRIC ACID TYPE A RECEPTOR SUBUNIT ALPHA2)
    
57. EGR1 (AT225; EARLY GROWTH RESPONSE 1; G0S30; KROX 24; KROX24; NGFI A; NGFIA; TIS8; ZIF 268; ZIF268; ZNF225)
    
58. NOS1 (BNOS; IHPS1; N NOS; NC NOS; NCNOS; NITRIC OXIDE SYNTHASE 1; NNOS; NNOS)
    
59. ANKK1 (ANKYRIN REPEAT AND KINASE DOMAIN CONTAINING 1; PKK2; SGK288)
    
60. CYP3A4 (CP33; CP34; CYP3A; CYP3A3; CYPIIIA3; CYPIIIA4; CYTOCHROME P450 FAMILY 3 SUBFAMILY A MEMBER 4; NF 25; NF25; P450C3; P450PCN1)
    
61. PCDHA4 (CNR1; CNRN1; CRNR1; PCDH ALPHA4; PCDHALPHA4; PROTOCADHERIN ALPHA 4)
    
62. IL10 (CSIF; GVHDS; IL 10; IL10A; INTERLEUKIN 10; INTERLEUKIN10; TGIF)
    
63. MTOR (FRAP; FRAP1; FRAP2; MECHANISTIC TARGET OF RAPAMYCIN KINASE; RAFT1; RAPT1)
    
64. TRH (PRO TRH; PROTRH; THYROTROPIN RELEASING HORMONE)
    
65. CHRNB4 (CHOLINERGIC RECEPTOR NICOTINIC BETA 4 SUBUNIT)
    
66. GRM1 (GLUTAMATE METABOTROPIC RECEPTOR 1; GPRC1A; MGLU1; MGLUR1; PPP1R85; SCA44; SCAR13)
    
67. GDNF (ATF1; ATF2; GLIAL CELL DERIVED NEUROTROPHIC FACTOR; HFB1 GDNF; HFB1GDNF; HSCR3)
    
68. DRD1 (DADR; DOPAMINE RECEPTOR D1; DRD1A)
    
69. GRIN1 (GLUN1; GLUTAMATE IONOTROPIC RECEPTOR NMDA TYPE SUBUNIT 1; MRD8; NDHMSD; NDHMSR; NMD R1; NMDA1; NMDAR1; NMDR1)
    
70. BCHE (BCHED; BUTYRYLCHOLINESTERASE; CHE1; CHE2)
    
71. CCL2 (C C MOTIF CHEMOKINE LIGAND 2; GDCF 2; GDCF2; HC11; HSMCR30; MCAF; MCP 1; MCP1; SCYA2; SMC CF; SMCCF)
    
72. ADH1C (ADH3; ALCOHOL DEHYDROGENASE 1C CLASS I , GAMMA POLYPEPTIDE)
    
73. WARS1 (GAMMA 2; GAMMA2; HMN9; IFI53; IFP53; TRYPTOPHANYL TRNA SYNTHETASE 1; WARS)
    
74. ADH4 (ADH 2; ADH2; ALCOHOL DEHYDROGENASE 4 CLASS II , PI POLYPEPTIDE; HEL S 4)
    
75. PTGS2 (COX 2; COX2; GRIPGHS; HCOX 2; HCOX2; PGG/HS; PGHS 2; PGHS2; PHS 2; PHS2; PROSTAGLANDIN ENDOPEROXIDE SYNTHASE 2)
    
76. HDAC9 (HD7B; HDAC; HDAC7; HDAC7B; HDAC9B; HDAC9FL; HDRP; HISTONE DEACETYLASE 9; MITR)
    
77. RTN4 (NBLA00271; NBLA10545; NOGO; NSP CL; NSPCL; RETICULON 4; RETICULON4; RTN X; RTN4 A; RTN4 B1; RTN4 B2; RTN4 C; RTN4A; RTN4B1; RTN4B2; RTN4C; RTNX)
    
78. PPP1R1B (DARPP 32; DARPP32; PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 1B)
    
79. PPARA (HPPAR; NR1C1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PPAR; PPARALPHA)
    
80. BAX (BCL2 ASSOCIATED X, APOPTOSIS REGULATOR; BCL2L4)
    
81. OPRK1 (K OR 1; KOR 1; KOR1; OPIOID RECEPTOR KAPPA 1; OPRK)
    
82. DRD3 (D3DR; DOPAMINE RECEPTOR D3; ETM1; FET1)
    
83. BCL2 (BCL 2; BCL2; BCL2 APOPTOSIS REGULATOR; PPP1R50)
    
84. HOMER1 (HOMER; HOMER SCAFFOLD PROTEIN 1; HOMER1A; HOMER1B; HOMER1C; SYN47; VES 1; VES1)
    
85. EGFR (EPIDERMAL GROWTH FACTOR RECEPTOR; ERBB; ERBB1; HER1; MENA; NISBD2; PIG61)
    
86. ACHE (ACEE; ACETYLCHOLINESTERASE CARTWRIGHT BLOOD GROUP; ARACHE; N ACHE; NACHE)
    
87. ADORA2A (A2AR; ADENOSINE A2A RECEPTOR; ADORA2; RDC8)
    
88. ABCB1 (ABC20; ATP BINDING CASSETTE SUBFAMILY B MEMBER 1; CD243; CLCS; GP170; MDR1; P GP; PGY1)
    
89. MGLL (HU K5; HUK5; MAGL; MONOGLYCERIDE LIPASE; MONOGLYCERIDELIPASE)
    
90. CDK5 (CYCLIN DEPENDENT KINASE 5; LIS7; PSSALRE)
    
91. PSENEN (ACNINV2; MDS033; MSTP064; PEN 2; PEN2; PRESENILIN ENHANCER, GAMMA SECRETASE SUBUNIT)
    
92. SH2D3C (CHAT; NSP3; PRO34088; SH2 DOMAIN CONTAINING 3C; SHEP1)
    
93. IL1B (IL 1; IL1 BETA; IL1BETA; IL1BETA; IL1F2; INTERLEUKIN 1 BETA)
    
94. CHAT (CHOACTASE; CHOLINE O ACETYLTRANSFERASE; CMS1A; CMS1A2; CMS6)
    
95. CCL4 (ACT2; AT744.1; C C MOTIF CHEMOKINE LIGAND 4; G 26; HC21; LAG 1; LAG1; MIP 1 BETA; MIP1B; MIP1B1; SCYA2; SCYA4)
    
96. CALCA (CALC1; CALCITONIN RELATED POLYPEPTIDE ALPHA; CGRP; CGRP ALPHA; CGRP I; CGRP1; CGRPALPHA; CGRPI)
    
97. S100A12 (CAAF1; CAGC; CGRP; MRP 6; MRP6; S100 CALCIUM BINDING PROTEIN A12)
    
98. OPRD1 (DOR1; OPIOID RECEPTOR DELTA 1; OPRD)
    
99. JUNB (AP 1; JUNB PROTO ONCOGENE, AP 1 TRANSCRIPTION FACTOR SUBUNIT)
    
100. GSTM1 (GLUTATHIONE S TRANSFERASE MU 1; GST1; GSTM1 1; GSTM11; GSTM1A 1A; GSTM1A1A; GSTM1B 1B; GSTM1B1B; GTH4; GTM1; H B; MU 1)