mRNA expressions of their receptors (OXTR, CRHR1 and CRHR2) were determined in anterior cingulate cortex and dorsolateral prefrontal cortex (DLPFC) of 30 BD and 34 BD controls, and 24 MDD and 12 MDD controls. PMID:36126617
Methylation analyses of 9 promoter/regulatory regions of genes known to be implicated in depression/PTSD (ADCYAP1, BDNF, CRHR1, DRD2, IGF2, LSD1/KDM1A, NR3C1, OXTR, SLC6A4) were performed on DNA from blood samples by the MassARRAY EpiTYPER platform, with MassCleave settings. PMID:36001138
Methylation levels were increased in genes regulating HPA axis (CRHR1) and dopamine neurotransmission (DRD2 and LSD1), thus supporting the involvement of these biological processes in depression/PTSD and indicating that methylation of these genes can be modulated by stress conditions, such as working as healthcare front line during COVID 19 pandemic. PMID:36001138
Highly integrated expression of HPA axis, neuro inflammatory, BDNF, monoamine, GABA, cannabinoid and opioid signalling genes was confirmed across conditions, and consistent/potentially causal correlations identified for (i) locomotor activity (noradrenaline, ghrelin; FC Crhr1, Tnfrsf1b, Il33, Nfkb1, Maoa, Gabra1; hippocampal Il33); (ii) thigmotaxis (adrenaline, leptin); (iii) anxiety like behaviour (adrenaline, leptin; FC Tnfrsf1a; hippocampal Il33); (iv) depressive like behaviour (ghrelin; FC/hippocampal s100a8); and (v) cardiac stress resistance (noradrenaline, leptin; FC Il33, Tnfrsf1b, Htr1a, Gabra1, Gabrg2; hippocampal Il33, Tnfrsf1a, Maoa, Drd2). PMID:35763309
The role of rs242941, rs1876828, rs242939 and rs110402 polymorphisms of CRHR1 gene and the depression: systematic review and meta analysis. PMID:34279801
Several studies have evaluated the possible association between polymorphisms or variants in Corticotropin releasing hormone 1 receptor gene (CRHR1) with depression; however, results remain contradictory and heterogeneous. PMID:34279801
To our knowledge, we conducted the first comprehensive systematic review and meta analysis evaluating the association of the CRHR1 gene and the risk of depression. PMID:34279801
A search online was conducted in databases for any CRHR1 genetic association studies in depression. PMID:34279801
We found a significant association of rs242941, rs1876828 and rs242939 variants of the CRHR1 gene with depression. PMID:34279801
No association of CRHR1 rs110402 and depression was observed. PMID:34279801
Our meta analysis shows that some variants of the CRHR1 gene (rs242941, rs1876828 and rs242939) might confer susceptibility to depression. PMID:34279801
More than 3200 Caucasian outpatients with a major depressive episode (MDE) from real life settings were herein analyzed for clinical response to tianeptine, a treatment initiated from 79.5% of the subjects, during 6 8 weeks follow up, assessing polymorphisms targeting four genes involved in the HPA axis (NR3C1, FKPB5, CRHR1, and AVPR1B). PMID:33154348
We found a significant association (p < 0.001) between CRHR1 gene variants rs878886 and rs16940665, or haplotype rs878886*C rs16940665*T, and tianeptine antidepressant response and remission according to the hospital anxiety and depression scale. PMID:33154348
As the Hypothalamic Pituitary Adrenal (HPA) axis might be implicated in suicidal behavior, we assessed the relationship between TESI and single nucleotide polymorphisms (SNPs) in the HPA axis implicated NR3C1 (n = 7 SNPs), FKBP5 (n = 5 SNPs), AVPR1B (n = 1 SNPs), CRHR1 (n = 1 SNPs), and SKA2 (n = 1 SNPs) genes, in a sample of 3566 adult outpatients with depression for whom an antidepressant treatment was introduced. PMID:32952155
In contrast, CRHR1 TCA haplotype (rs7209436, rs4792887, rs110402), CRHR1 rs17689882, and CRHR1 rs110402 showed protective effects on depression and depressive symptoms among individuals with a history of maltreatment. PMID:32697690
In contrast, CRHR1 TCA haplotype (rs7209436, rs4792887, rs110402), CRHR1 rs17689882, and CRHR1 rs110402 showed protective effects on depression and depressive symptoms among individuals with a history of maltreatment. PMID:32697690
Variants in the single nucleotide polymorphism (SNP) rs110402 of the corticotropin releasing hormone receptor type I (CRHR1) gene have been shown in interaction with childhood maltreatment to increase the vulnerability to develop depressive symptoms in adulthood. PMID:32361186
Aneurysmal subarachnoid haemorrhage: effect of CRHR1 genotype on fatigue and depression. PMID:32305063
CRHR1 minor genotype was associated with a lower risk of fatigue and depression after aSAH. PMID:32305063
We included studies investigating GxE interactions between HPA axis genes [Angiotensin Converting Enzyme (ACE), Arginine Vasopressin (AVP), Corticotrophin Releasing Hormone (CRH), Corticotrophin Releasing Hormone Receptor 1 (CRHR1), Corticotrophin Releasing Hormone Receptor 2 (CRHR2), FK506 binding protein (FKBP5), Nuclear Receptor subfamily 3 group C member 1 (NR3C1), Nuclear Receptor subfamily 3 group C member 2 (NR3C2)] and CM in depression. PMID:31902387
Increasing evidence have indicated the strong association of stress, especially the chronic stress and early life stress, with depressive disorders development, while the association of stress with depression is moderated by genetic risk factors, including polymorphism of SERT, BDNF, GR, FKBP5, MR, and CRHR1. PMID:31784962
Increasing evidence have indicated the strong association of stress, especially the chronic stress and early life stress, with depressive disorders development, while the association of stress with depression is moderated by genetic risk factors, including polymorphism of SERT, BDNF, GR, FKBP5, MR, and CRHR1. PMID:31784962
Neither early life adversity nor CRHR1 blockade in the adult influenced anxiety or depression related behaviors. PMID:31698409
DNAm levels within CpG sites in NR3C1, CRH, CRHR1, and CRHR2 were associated with risk for MDD across adolescence and young adulthood. PMID:31582756
We assess the effects of CRHR1 variant (rs17689918) by environment interactions on emotionality and behavioral traits, including anxiety, depression, aggression and antisocial behaviors. PMID:29772307
CRH/CRHR1 mediates prenatal synthetic glucocorticoid programming of depression like behavior across 2 generations. PMID:29543532
Administration of a CRHR1 antagonist to newborn F1 Dex offspring alleviated depression like behavior in these rats at adult. PMID:29543532
Our results revealed that prenatal sGC exposure could program Crh and Crhr1 gene expression in hippocampus across 2 generations, thereby leading to depression like behavior. PMID:29543532
Xu, Y. J., Sheng, H., Wu, T. W., Bao, Q. Y., Zheng, Y., Zhang, Y. M., Gong, Y. X., Lu, J. Q., You, Z. D., Xia, Y., Ni, X. CRH/CRHR1 mediates prenatal synthetic glucocorticoid programming of depression like behavior across 2 generations. PMID:29543532
A haplotype of alleles T A T in a set of common polymorphisms in the gene encoding for CRF1 (CRHR1) has been associated with both depression vulnerability and alterations in cognitive functioning. PMID:29317606
These data demonstrate that the CRHR1 TAT haplotype is associated with cognitive features of depression including difficulty with decision making, higher rumination, and poorer learning and memory. PMID:29317606
Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS to predict depression, cognitive functions and hippocampal activity. PMID:28461011
Using MeDIP analysis in genomic DNA isolated from peripheral blood mononuclear cells (PBMC) of healthy controls (n = 20), MDD patients with (n = 14) or without serious suicidal ideation (n = 10), we studied methylation of the stress associated genes, Brain Derived Neurotrophic Factor (BDNF), Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1), FK506 Binding Protein 5 (FKBP5), Corticotropin Releasing Hormone Binding Protein (CRHBP), and Corticotropin Releasing Hormone Receptor 1 (CRHR1). PMID:28246044
Here we investigate the short and long term effects of adolescent chronic mild stress (CMS) on the emergence of anxiety /depressive like behaviors (open field and forced swim test FST) and on HPA activity (corticosterone and type 1 CRH receptor CRHR1) in PAE male and female rats. PMID:27567117
In a case control study design, we examined whether single nucleotide polymorphisms (SNPs) and haploid genotype (haplotype) associations of MR gene NR3C2, GR gene NR3C1 and genes of GR chaperone molecules FK506 binding protein 5 (FKBP5) and corticotrophin releasing hormone receptor 1 (CRHR1) differed between healthy subjects (n = 634) and inpatients with major depressive disorder (n = 412). PMID:27549215
In contrast, NR3C2, FKBP5 and CRHR1 polymorphisms were not significantly associated with MDD. PMID:27549215
The corticotropin releasing hormone receptor 1 (CRHR1) gene has been repeatedly implicated in Major Depressive Disorder (MDD) in humans and animal models; however, the findings are not absolutely convergent. PMID:27544317
The corticotropin releasing hormone receptor 1 (CRHR1) gene has been repeatedly implicated in Major Depressive Disorder (MDD) in humans and animal models; however, the findings are not absolutely convergent. PMID:27544317
Since recent evidence from genome wide association studies suggests that narrowing the phenotypic heterogeneity may be crucial in genetic studies of MDD, the aim of this study was to evaluate the effects of CRHR1 polymorphisms on MDD while addressing the influence of sex and smoking status. PMID:27544317
The association of the CRHR1 SNPs rs12944712, rs110402, and rs878886 with MDD was evaluated in 629 Brazilian adults of European descent recruited from the general population [180 (28.6%) with lifetime MDD]. PMID:27544317
Among lifetime smokers, there were no significant associations between CRHR1 SNPs and MDD LIMITATIONS: The lack of a depression rating scale; scarcity of information on the functionality of the CRHR1 SNPs; and relatively small sample sizes in some subgroups. PMID:27544317
Among lifetime smokers, there were no significant associations between CRHR1 SNPs and MDD LIMITATIONS: The lack of a depression rating scale; scarcity of information on the functionality of the CRHR1 SNPs; and relatively small sample sizes in some subgroups. PMID:27544317
Our results strengthen the evidence for the role of CRHR1 SNPs in MDD susceptibility and suggest that their effects may be modulated by sex and smoking status. PMID:27544317
Activation of CRHR1 receptors regulates social and depressive like behaviors and expression of BDNF and TrkB in mesocorticolimbic regions following global cerebral ischemia. PMID:27498336
The current study investigates the impact of CRHR1 blockade on BDNF/TrkB signaling expression in the mesolimbic circuitry, and social and depressive like behavior following global ischemia. PMID:27498336
However, none of the SNPs located within AVP, CRH, CRHR1, CRHR2, FKBP5 or NC3C1 were associated with depression. PMID:27264499
reported that children carrying at least one copy of a CRHR1 TAT haplotype reported less brooding than their peers in the presence of maternal depression. PMID:27073970
Similar to Woody et al., we found an interaction between CRHR1 SNPs and maternal depression, with the homozygous minor genotype acting as a protective factor against brooding in the presence of maternal depression. PMID:27073970
Plasma levels of AVP, CRH, and ACTH were determined as well as participation of their receptors in the expression of depression related behavior and gene expression of AVP and CRH receptors (AVPr1b, CRHR1, and CRHR2) in the pituitary gland. PMID:26700241
One SNP (rs623580) located in the tryptophan hydroxylase 1 gene (TPH1; chromosome 11), one intergenic variant (rs9526236) upstream of the 5 hydroxytryptamine receptor 2A gene (HTR2A; chromosome 13), and five polymorphisms (rs17689966, rs173365, rs7209436, rs110402, and rs242924) located in the corticotropin releasing hormone receptor 1 gene (CRHR1; chromosome 17), all showed suggestive trends for association with MDD (P<0.05). PMID:26543368
Within CRHR1 gene, the TATGA haplotype combination was found to increase significantly the risk for MDD with an odds ratio =1.68 (95% CI: 1.16 2.42, P=0.006). PMID:26543368
There was no statistically significant association of perinatal depression for CRHR1 rs242941 and GR rs41423247 (BclI). PMID:26518448
When all subjects were grouped based on family history of mental illness, there was a statistically significant association of CRHR1 rs242941 with family history regardless of depression status (P = 0.043). PMID:26518448
The purpose of this study was to use pooled data from two independent studies of rural African American youths to test the moderation effect of the corticotropin releasing hormone receptor 1 gene (CRHR1) on the link between family economic hardship and trajectories of depressive symptoms. PMID:26206446
Growth curve models were executed to determine whether CRHR1 moderated the link between Wave 1 family economic hardship and youths' development of depression. PMID:26206446
When exposed to family economic hardship 1 standard deviation above the mean at Wave 1, youths who scored 0 on the CRHR1 index showed high and increasing depressive symptoms across time, whereas those who scored 2 on the index showed a decrease in depressive symptoms. PMID:26206446
The CRHR1 gene reduces the risk for depressive symptoms among youths living in families undergoing high levels of economic hardship. PMID:26206446
Variants in the corticotropin releasing hormone receptor 1 (CRHR1) gene have been associated with alcoholism and depression. PMID:25802844
Influence of maternal depression on children's brooding rumination: Moderation by CRHR1 TAT haplotype. PMID:25648046
Therefore, the goal of the current study was to examine levels of brooding in children of mothers with a history of MDD (n = 129) compared to children of never depressed mothers (n = 126) and to determine whether the variation in a gene known to influence hypothalamic pituitary adrenal axis functioning corticotropin releasing hormone receptor 1 (CRHR1) would moderate the link between maternal MDD and children's levels of brooding. PMID:25648046
We predicted children of mothers with a history of MDD would exhibit higher levels of brooding than children of mothers with no lifetime depression history but that this link would be stronger among children carrying no copies of the protective CRHR1 TAT haplotype. PMID:25648046
We predicted children of mothers with a history of MDD would exhibit higher levels of brooding than children of mothers with no lifetime depression history but that this link would be stronger among children carrying no copies of the protective CRHR1 TAT haplotype. PMID:25648046
Our results supported these hypotheses and suggest that the development of brooding among children of depressed mothers, particularly children without the protective CRHR1 haplotype, may serve as an important mechanism of risk for the intergenerational transmission of depression. PMID:25648046
Specifically, we investigated whether genotypic variation in corticotropin releasing hormone receptor 1 (CRHR1) and the linked polymorphic region of the serotonin transporter gene (5 HTTLPR) moderated effects of IPT on depressive symptoms over time. PMID:25640828
The results revealed that changes in depressive symptoms over time depended on both intervention group and genotypes (5 HTTLPR and CRHR1). PMID:25640828
Moreover, multiple group path analysis indicated that IPT improved depressive symptoms, increased social adjustment, and decreased perceived stress at posttreatment among women with the 0 copies of the CRHR1 TAT haplotype only. PMID:25640828
Previous research supports gene environment interactions for polymorphisms in the corticotropin hormone receptor 1 gene (CRHR1) and the serotonin transporter gene linked polymorphic region (5 HTTLPR) in predicting depression, but it has rarely considered genetic influences on stress sensitization processes, whereby early adversities (EA) increase depressive reactivity to proximal stressors later in life. PMID:25422958
Previous research supports gene environment interactions for polymorphisms in the corticotropin hormone receptor 1 gene (CRHR1) and the serotonin transporter gene linked polymorphic region (5 HTTLPR) in predicting depression, but it has rarely considered genetic influences on stress sensitization processes, whereby early adversities (EA) increase depressive reactivity to proximal stressors later in life. PMID:25422958
Participants were assessed prospectively for EA up to age 5 and recent chronic stress and depressive symptoms at age 20 and genotyped for CRHR1 single nucleotide polymorphism rs110402 and 5 HTTLPR. PMID:25422958
CRHR1 A alleles and 5 HTTLPR short alleles were associated with greater stress sensitization (i.e., greater depressive reactivity to chronic stress for those also exposed to high levels of EA). PMID:25422958
Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5 HTTLPR), brain derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children. PMID:25422957
Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS experience to predict depression as well as neuroendocrine and neuronal reactivity. PMID:24931706
Histone modifications of the Crhr1 gene in a rat model of depression following chronic stress. PMID:24867333
Multiple lines of evidence suggest a link between depression and changes in hypothalamic pituitary adrenal (HPA) axis hormone dynamics, including altered regulation of the corticotrophin releasing hormone (CRH) and its main receptor, corticotrophin releasing hormone receptor 1 (CRHR1). PMID:24867333
These data are the first in vivo evidence of a role for chromatin modifications in the regulation of Crhr1 gene expression in the hypothalamus, and may provide novel insight into therapeutic approaches to treat depression. PMID:24867333
We hypothesize that HPA axis hyperactivation may be due to variants in the genes of the CRH receptors (CRHR1, CRHR2), corticotropin receptors (or melanocortin receptors, MC1R MC5R), glucocorticoid receptor (NR3C1), mineralocorticoid receptor (NR3C2), and of the FK506 binding protein 51 (FKBP5), and that these variants may be partially responsible for the clinical association of depression, T2D and MetS. PMID:24817815
In this review, we will focus on the correlation of stress, HPA axis hyperactivation, and the possible genetic role of the CRHR1, CRHR2, MCR1 5, NR3C1, and NR3C2 receptors and FKBP5 in the susceptibility to the comorbidity of depression, T2D, and MetS. PMID:24817815
The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in genes of the stress hormone signaling pathway, specifically FKBP5, NR3C1, and CRHR1, are associated with depressive symptoms during and after pregnancy. PMID:24741566
The analysed candidate haplotypes in FKBP5, NR3C1, and CRHR1 did not show an association with depression scores as assessed by EPDS in this cohort of healthy unselected pregnant women. PMID:24741566
The corticotropin releasing hormone (CRH) and the CRH receptor 1 (CRHR1) have been implicated in the link between early life adversity and adult anxiety and depression, with rodent studies identifying the very early postnatal period as highly susceptible to this programming. PMID:24630468
In addition, GR and corticotropin releasing hormone receptor 1 (CRHR1) genotypes contributed significantly to psychosis measures and CRHR1 contributed significantly to depression severity rating. PMID:24166410
To determine if single nucleotide polymorphisms of the corticotrophin releasing hormone binding protein (CRHBP, rs10055255) and CRH receptor type 1 (CRHR1, rs1876831) were associated with posttraumatic stress disorder (PTSD) and depressive symptoms following medical surgical intensive care unit (ICU) hospitalization. PMID:24075295
Carrying a CRHR1 rs1876831 C allele was associated with significantly more post ICU depressive symptoms compared to T/T homozygotes (C/T heterozygtes: β = 6.9, 95% CI, 1.2 12.6; P = .02; C/C homozygotes: β = 5.8; 95% CI: 0.2 11.3; P = .04). PMID:24075295
Epistatic interaction between CRHR1 and AVPR1b variants as a predictor of major depressive disorder. PMID:23962971
The aim of this study was to analyze the possible association of CRHR1 and AVPR1b gene variants with bipolar disorder and major depressive disorder (MDD). PMID:23962971
The aim of this study was to analyze the possible association of CRHR1 and AVPR1b gene variants with bipolar disorder and major depressive disorder (MDD). PMID:23962971
We observed strong linkage disequilibrium between seven CRHR1 polymorphisms grouped in two haplotype blocks; however, none of them showed an association with MDD or bipolar disorder. PMID:23962971
Gene gene interaction analysis revealed a significant epistatic interaction between AVPR1b and CRHR1 genes in susceptibility to MDD (P=0.017). PMID:23962971
The BclI and ER22/23EK single nucleotide polymorphisms (SNPs) of the GR and the haplotype tagged rs1876828, rs242939 and rs242941 SNPs of the CRHR1 associated with genetic risk to depressive disorders were genotyped. PMID:23726670
As a major mediator of the stress response, corticotropin releasing hormone receptor 1 (CRHR1) has been demonstrated to be an important contributor to the pathogenesis of MDD. PMID:23529111
In this study, we show a significant increase in the G allele (rs242939) of the CRHR1 gene in the recurrent MDD group compared with the control group, and an overrepresentation of G G T hyplotype of the CRHR1 gene in recurrent MDD. PMID:23529111
We also demonstrate the interaction of the CRHR1 gene and negative life events in recurrent MDD. PMID:23529111
These results suggest that the CRHR1 gene could modify the susceptibility to developing recurrent MDD following negative life events in adulthood. PMID:23529111
As a result of haplotype analysis of CRHR genes in depression and panic disorder patients, it was found that genetic polymorphism of CRHR1 and CRHR2 was related to both disorders. PMID:23198596
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM IV. PMID:23157339
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM IV. PMID:23157339
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM IV. PMID:23157339
CRHR1 genotypes, neural circuits and the diathesis for anxiety and depression. PMID:23147386
No association between polymorphisms and haplotypes of the AVPR1b, CRHR1 and NR3C1 genes and depression with melancholic features in the course of bipolar disorder. PMID:23068076
No association was found for alleles, genotypes, or haplotype analysis for NR3C1, AVPR1b, and CRHR1 genes and melancholic depression. PMID:23068076
LA transcriptome affected by CMS was associated with genes involved in behavioral response to stimulus (Fcer1g, Rasd2, S100a8, S100a9, Crhr1, Grm5, and Prkcc), immune effector processes (Fcer1g, Mpo, and Igh VJ558), diacylglycerol binding (Rasgrp1, Dgke, Dgkg, and Prkcc), and long term depression (Crhr1, Grm5, and Prkcc) and/or coding elements of dendrites (Crmp1, Cntnap4, and Prkcc) and myelin proteins (Gpm6a, Mal, and Mog). PMID:22836882
Accumulating research suggests a moderating role for the corticotropin releasing hormone receptor 1 gene (CRHR1) in the association between childhood adversity and adult depression. PMID:22748421
300 participants (137 males, 163 females) were genotyped for four CRHR1 SNPs (rs7209436, rs110402, rs242924, and rs17689882) and completed the Beck Depression Inventory at ages 19, 22 and 23 years. PMID:22748421
Our results indicate that CRHR1 and childhood adversity interacted to predict depressive symptoms in young adults. PMID:22748421
Specifically, we found that the impact of childhood maltreatment on adult depressive symptoms was significantly higher in individuals (i) with two copies of the CRHR1 TAT haplotype, and (ii) homozygous for the G allele of rs17689882. PMID:22748421
The present study partially replicates recent findings of a CRHR1 by childhood adversity interaction with regard to adult depression highlighting the subjective characteristics of the environmental pathogen that is operative in this interaction. PMID:22748421
Its cognate receptor CRH receptor type 1 (CRHR1) is a potential novel target for the therapeutic intervention in major depressive disorder. PMID:22659651
Depression and anxiety symptoms among women who carry the FMR1 premutation: impact of raising a child with fragile X syndrome is moderated by CRHR1 polymorphisms. PMID:22573456
Association of CRHR1 and CRHR2 with major depressive disorder and panic disorder in a Japanese population. PMID:22467522
Dysregulation of the stress response of the hypothalamic pituitary adrenal axis, including the corticotrophin releasing hormone (CRH) signaling via primary receptors (CRHR1 and CRHR2), is considered to play a major role for onset and recurrence in MDD and PD. PMID:22467522
To confirm the association of CRHR1 and CRHR2 with MDD and PD, we investigated 12 single nucleotide polymorphisms (SNPs) (rs4076452, rs7209436, rs110402, rs242924, rs242940, and rs173365 for CRHR1 and rs4722999, rs3779250, rs2267710, rs1076292, rs2284217, and rs226771 for CRHR2) in MDD patients (n = 173), PD patients (n = 180), and healthy controls (n = 285). PMID:22467522
The SNP rs110402 and rs242924 in the CRHR1 gene and the rs3779250 in the CRHR2 gene were associated with MDD. PMID:22467522
The T A T G G haplotype consisting of rs7209436 and rs173365 in CRHR1 was positively associated with MDD. PMID:22467522
The T A haplotype consisting of rs7209436 and rs110402 in CRHR1 was positively associated with MDD. PMID:22467522
These results provide support for an association of CRHR1 and CRHR2 with MDD and PD. PMID:22467522
CRHR1 was genotyped in 83 controls and a preliminary sample of 16 unmedicated patients with MDD who completed a functional magnetic resonance imaging scan while viewing blocks of positive, negative, and neutral words. PMID:22378896
Results from healthy controls and a preliminary sample of MDD participants show that CRHR1 single nucleotide polymorphism rs110402 moderates neural responses to emotional stimuli, suggesting a potential mechanism of vulnerability for the development of MDD. PMID:22378896
Only rs4792888 in CRHR1 showed modest evidence of association with duloxetine response in MDD (P=0.029 in GAD, P=0.054 in MDD). PMID:22249355
Interaction between CRHR1 and BDNF genes increases the risk of recurrent major depressive disorder in Chinese population. PMID:22194899
The aim of this study is to examine the single and combined effects of CRH receptor 1 (CRHR1) and BDNF genes in recurrent major depressive disorder (MDD). PMID:22194899
The aim of this study is to examine the single and combined effects of CRH receptor 1 (CRHR1) and BDNF genes in recurrent major depressive disorder (MDD). PMID:22194899
Whether genetic variations interaction between CRHR1 and BDNF genes might be associated with increased susceptibility to recurrent MDD was studied by using a gene based association analysis of single nucleotide polymorphisms (SNPs). PMID:22194899
CRHR1 gene (rs1876828, rs242939 and rs242941) and BDNF gene (rs6265) were identified in the samples of patients diagnosed with recurrent MDD and matched controls. PMID:22194899
Allelic association between CRHR1 rs242939 and recurrent MDD was found in our sample (allelic: p = 0.018, genotypic: p = 0.022) with an Odds Ratio 0.454 (95% CI 0.266 0.775). PMID:22194899
Our results suggest that an interaction between CRHR1 and BDNF genes constitutes susceptibility to recurrent MDD. PMID:22194899
A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African American women. PMID:21998007
Adverse childhood experiences (ACEs) increase the risk for adult depression and substance dependence, possibly mediated by the corticotropin releasing hormone type 1 receptor (CRHR1). PMID:21998007
In some studies, a three SNP "T A T" haplotype in CRHR1, which encodes CRHR1, exerted a protective moderating effect on risk of depression in adults with ACEs. PMID:21998007
The complex structure of CRHR1 may help to explain why some variants in the gene moderate the effects of an ACE only on depression risk while others moderate the effect of an ACE only on AD risk. PMID:21998007
In the present study, we compared the anxiety profile and CRHR1 and AVPR1b expression levels in control Sprague Dawley (SD) rats and rats of the SD derived Flinders Sensitive Line (FSL), a genetic model of depression. PMID:21839808
Maternal depression and child and adolescent depression symptoms: an exploratory test for moderation by CRHR1, FKBP5 and NR3C1 gene variants. PMID:21789663
Variation in three polymorphisms of the CRHR1 gene has been found to moderate the association of childhood maltreatment with depression, and we hypothesized that it would also be linked to neuroticism. PMID:21438878
Recently, two studies have reported an interaction between childhood abuse and the TAT haplotype of the CRH Receptor Gene (CRHR1) connecting childhood adversities and genetic susceptibility to adult depression. PMID:20957648
Although we did not replicate the specific interaction of abuse and the TAT haplotype of the CRHR1 gene we confirmed the relevance of an interplay between variants within the CRHR1 gene and childhood adversities in the modulation of depression in adults. PMID:20957648
Variations of the corticotropin releasing hormone receptor 1 (CRHR1) gene appear to moderate the development of depression after childhood trauma. PMID:20161813
We examined sex differences in the effects of the CRHR1 gene on the relationship between childhood trauma and adult depression. PMID:20161813
Our results suggest that the CRHR1 gene may only moderate the effects of specific types of childhood trauma on depression. PMID:20161813
Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms. PMID:20029939
Gene x environment (G x E) interactions mediating depressive symptoms have been separately identified in the stress sensitive serotonergic (5 HTTLPR) and corticotropin releasing hormone (CRHR1) systems. PMID:20029939
We used an association study examining G x G x E interactions of CRHR1 and 5 HTTLPR polymorphisms and measures of child abuse on adult depressive symptomatology. PMID:20029939
We found that the 5 HTTLPR S allele interacted with CRHR1 haplotypes and child abuse to predict current depressive symptoms (N = 856, P = 0.016). PMID:20029939
These data suggest that G x E interactions predictive of depressive symptoms may be differentially sensitive to levels of childhood trauma, and the effects of child abuse are moderated by genetic variation at both the CRHR1 and 5 HTTLPR loci and by their G x G interaction. PMID:20029939
Recent clinical studies in depressed patients showed that CRHR1 antagonists improve clinical symptoms of anxiety and depression and reduce stress hormone release following psychosocial stress. PMID:19906235
Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican Americans. PMID:19844206
Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension. PMID:19736354
A previous study reported a gene x environment interaction in which a haplotype in the corticotropin releasing hormone receptor 1 gene (CRHR1) was associated with protection against adult depressive symptoms in individuals who were maltreated as children (as assessed by the Childhood Trauma Questionnaire [CTQ]). PMID:19736354
To replicate the interaction between childhood maltreatment and a TAT haplotype formed by rs7209436, rs110402, and rs242924 in CRHR1, predicting adult depression. PMID:19736354
A haplotype in CRHR1 has been suggested to exert a protective effect against adult depression among research participants who reported maltreatment on the CTQ, a measure that elicits emotional memories. PMID:19736354
Variation in the corticotropin releasing hormone receptor (CRHR1) gene has been shown to interact with early life stress to predict adult depression. PMID:19596121
This study was conducted to determine whether CRHR1 polymorphisms interact with childhood maltreatment to predict hypothalamic pituitary adrenal (HPA) axis reactivity, which has been linked to both depression and early life stress. PMID:19596121
We also found suggestive associations in women for GAD1, GRIA3, and BDNF with depression accompanied by fatigue, and for CRHR1 with depression accompanied by early morning awakenings. PMID:19548263
Depression in suicidal males: genetic risk variants in the CRHR1 gene. PMID:19220485
Dysregulation in the stress response of the hypothalamic pituitary adrenal axis, involving the corticotrophin releasing hormone and its main receptor (CRHR1), is considered to play a major role in depression and suicidal behavior. PMID:19220485
To comprehensively map the genetic variation in CRHR1 in relation to suicidality and depression, as a follow up to our initial report on SNP rs4792887, we analyzed six new single nucleotide polymorphisms (SNPs), in an extended sample of family trios (n = 672) with suicide attempter offspring, by using family based association tests. PMID:19220485
Moreover, five (Htr2a, Ntrk3, Crhr1, Ntrk2 and Crh) of the genes classically related to human major depression were differentially expressed in at least one of these models. PMID:18363858
To examine whether the effects of child abuse on adult depressive symptoms are moderated by genetic polymorphisms within the corticotropin releasing hormone type 1 receptor (CRHR1) gene. PMID:18250257
Association study examining gene x environment interactions between genetic polymorphisms at the CRHR1 locus and measures of child abuse on adult depressive symptoms. PMID:18250257
Specific CRHR1 polymorphisms appeared to moderate the effect of child abuse on the risk for adult depressive symptoms. PMID:18250257
These data support the corticotropin releasing hormone hypothesis of depression and suggest that a gene x environment interaction is important for the expression of depressive symptoms in adults with CRHR1 risk or protective alleles who have a history of child abuse. PMID:18250257
These data support the corticotropin releasing hormone hypothesis of depression and suggest that a gene x environment interaction is important for the expression of depressive symptoms in adults with CRHR1 risk or protective alleles who have a history of child abuse. PMID:18250257
Our aim was to investigate the influence of genetic variants in CRHR1, CRHR2, CRH BP and FKBP5 genes on both the vulnerability for depression and the response to antidepressant treatment. PMID:17467808
rs110402, in CRHR1 gene, was associated with an increased risk to present a seasonal pattern and an early age of onset of the first depressive episode. PMID:17467808
Dysregulation in the stress response of the hypothalamic pituitary adrenocortical (HPA) axis, involving the corticotrophin releasing hormone (CRH) and its main receptor (CRHR1), is associated with depression, frequent among suicidal males. PMID:17376150
Unexpectedly, at lower frequencies (1, 5 or 10Hz), the resulting synaptic changes in CA1 neurons of Crhr1( / ) were systematically shifted towards long term depression (LTD). PMID:17316992
In this study, we tested whether the polymorphisms of three sites (rs1876828, rs242939 and rs242941) in corticotropin releasing hormone receptor1 (CRHR1) gene are related to 6 weeks fluoxetine antidepressant effect in 127 Han Chinese patients with MDD. PMID:17258395
The results support the idea that the CRHR1 gene is likely to be involved in the antidepressant response in MDD. PMID:17258395
In this article, whether genetic variations in the corticotropin releasing hormone receptor1 (CRHR1) gene might be associated with increased susceptibility to major depression was studied by using a gene based association analysis of single nucleotide polymorphisms (SNPs). PMID:16815632
Three SNPs were identified in CRHR1 gene and genotyped in the samples of patients diagnosed with major depression and matched controls. PMID:16815632
These results support the idea that the CRHR1 gene is likely to be involved in the genetic vulnerability for major depression. PMID:16815632
Studies using animal models of anxiety, as well as mouse mutants, in which the gene coding for the CRH type 1 receptor (CRHR1) was genetically deleted supported the notion that enhanced CRH/CRHR1 signaling underlies depression and anxiety disorders. PMID:15573022
An initial clinical study showed that CRHR1 antagonism has beneficial effects on depression and anxiety symptoms at doses unharmful to neuroendocrine stress responsivity. PMID:15573022
CRH receptor 1 (CRHR1), which we first mapped in the brain in 1994, has been implicated in the treatment of depression and anxiety. PMID:15365580
Because CRHR1 affects both depression and anxiety. PMID:15365580
A large body of preclinical and clinical evidence points to a key role of the corticotropin releasing hormone (CRH) receptor 1 subtype (CRHR1) in mediating CRH elicited effects in anxiety, depressive disorders and stress associated pathologies. PMID:15310462
The recent characterisation of several selective small molecule CRHR1 antagonists offers new possibilities for the treatment of anxiety and depression. PMID:15310462