NTRK2 and stress

    16 sentences in 14 studies


Sentence(s) describing systemic stress (classified using a deep learning model):
  1. The expression changes of genes such as Dgkq, Bdnf, Ntrk2, and Pde4b in the mouse cerebellum suggested a link between cerebellar function, synaptic plasticity, and the differential stress responses observed in susceptible and resilient mice. PMID:38280111
  2. The genome wide m6A assay and MeRIP qPCR results revealed that the m6A modifications of Akt3, Ntrk2, Braf, and Kidins220 mRNA were significantly altered in the hippocampi of UCMS mice after stress stimulation and were reversed by hypericin treatment. PMID:37175269
  3. Expression of plasticity genes Nr3c1, Creb1, Ntrk2; m6A modifying enzymes Fto, methyltransferase like (Mettl) 3 and 14; DNA methylation enzymes Dnmt1, Dnmt3a; transcription factor C/ebp α; and miRNA 124 3p were determined by quantitative polymerase chain reaction (qPCR) in the hippocampus of rats that showed susceptibility to develop stress induced depression (learned helplessness). PMID:36161325
  4. We aimed to study whether sequence variants in genes involved in stress regulation pathways: NTRK2 and BDNF, may be associated with awake bruxism susceptibility, clinical presentation, and patients' perceived stress level. PMID:34610834
  5. Ancestral stress regulated cortical miR 221 and miR 26 expression and their target genes, thus downregulating ntrk2 and map1a genes in males while downregulating crh and upregulating map1a genes in females. PMID:31011159
  6. Since sex specific endocrine mechanisms respond to environmental stimulus by altering the neuronal epigenome, we examined the genome wide profile of hippocampal 5hmC in female mice following exposure to acute stress and identified 363 differentially hydroxymethylated regions (DhMRs) linked to known (e.g., Nr3c1 and Ntrk2) and potentially novel genes associated with stress response and psychiatric disorders. PMID:27576189
  7. Research suggests that the expressions of brain derived neurotrophic factor (BDNF) and neurotrophic tyrosine kinase receptor type 2 (NTRK2) play important roles in brain adaptation to investigate stress. PMID:26445699
  8. These findings may provide insights into the partial effects of genetic mutations in BDNF and NTRK2 on stress tolerance and personality. PMID:26445699
  9. A composite additive risk score was derived from polymorphisms in 10 previously identified genes associated with stress response (ADCYAP1R1, COMT, CRHR1, DBH, DRD2, FAAH, FKBP5, NPY, NTRK2, and PCLO), and gene x treatment effects were examined. PMID:25188543
  10. Interestingly, chronic antidepressant treatment with the selective serotonin reuptake inhibitor, fluoxetine, prevented the stress induced Ntrk2 and PI3K pathway changes, but it had no effect on the MAPK/ERK pathway. PMID:23075086
  11. The aim of this study was to examine whether the NTRK2 and BDNF polymorphisms impact brain white matter connections in major depressive disorder and whether they may also have an interactive effect with environmental stress in the form of early life adversity. PMID:22609366
  12. The neuroplastic pathway, which includes cyclic adenosine monophosphate response element binding protein 1 (CREB1), brain derived neurotrophic factor (BDNF), and its receptor (neurotrophic tyrosine kinase receptor, type 2 [NTRK2]), plays a crucial role in the adaptation of brain to stress, and thus variations of these genes are plausible risk factors for depression. PMID:21215389
  13. Pharmacogenomic studies of antidepressant treatment emergent suicidal events in depressed patients report associations with polymorphisms in genes involved in transcription (CREB1), neuroprotection (BDNF and NTRK2), glutamatergic and noradrenergic neurotransmission (GRIA3, GRIK2 and ADRA2A), the stress and inflammatory responses (FKBP5 and IL28RA), and the synthesis of glycoproteins (PAPLN). PMID:20504254
  14. Using q value analysis for multiplicity correction, we found significant interactions between lithium response and SNPs (rs1387923 and rs1565445) in the gene encoding neurotrophic tyrosine kinase receptor type 2 (NTRK2) and suicidal ideation, and between SNP rs2064721 in the gene encoding inositol polyphosphate 1 phosphatase (INPP1) and post traumatic stress disorder. PMID:17570738



Sentence(s) describing celluar stress (classified using a deep learning model):
  1. Our finding suggests that BDNF acts via NTRK2 to induce development of pLE cells for maintenance of implantation and pregnancy by activating cell signaling via the PI3K and MAPK pathways and by inhibiting ER stress. PMID:28150859
  2. Of the three intracellular signalling pathways that are downstream of Ntrk2, real time quantitative PCR confirmed that only the PI3K AKT GSK3B and MAPK/ERK pathways were affected by sub chronic stress, with the PLCγ pathway unaffected. PMID:23075086