Due to the low blood brain barrier permeability of BDNF itself, we tested the effects of LM22A 4, a brain penetrant, small molecule ligand of the BDNF receptor TrkB (encoded by Ntrk2), on dendritic spine density and form in hippocampal pyramidal neurons and on behavioral phenotypes in female Mecp2 heterozygous (HET) mice. PMID:38785269
Four variants were associated with OP: rs114829316 (IQCJ), rs76603051, rs12214684 (MCHR2), and rs77303493 (RIN2), and two variants with BMD of lumbar spine (rs11855618, CGNL1) and hip (rs73480593, NTRK2), reaching the genome wide significance threshold of P ≤ 5E 08. PMID:38484114
Association between NTRK2 Polymorphisms, Hippocampal Volumes and Treatment Resistance in Major Depressive Disorder. PMID:38002980
We therefore hypothesized the possible role of BDNF and neurotrophic receptor tyrosine kinase 2 (NTRK2) related polymorphisms in affecting both hippocampal volumes and treatment resistance in MDD. PMID:38002980
General linear models and binary logistic regressions were employed to test the effect of genetic variations related to BDNF and NTRK2 on bilateral hippocampal volumes and treatment resistance, respectively. PMID:38002980
A significant association between one NTRK2 polymorphism with hippocampal volumes and antidepressant response was found, with significant indirect effects. PMID:38002980
The CORT treatment altered the morphology of the hippocampus and down regulated gene transcription for corticotropin releasing hormone (Crh) and its type 1 receptor (Crhr1), glucocorticoid receptor (Nr3c1), and brain derived neurotrophic factor Bdnf and its receptor Ntrk2 (neurotrophic receptor tyrosine kinase 2). PMID:37704081
Central administration of the Tau protein did not affect the expression of the Ntrk2, Ngfr, Mapt, Bax and Bcl 2 genes in the frontal cortex and hippocampus. PMID:37465194
Brain derived neurotrophic factor (Bdnf) and its receptor tropomyosin kinase receptor B (Ntrk2) were upregulated in the hypothalamus, hippocampus, and amygdala by implementing EE in BTBR mice, suggesting that BDNF TrkB signaling plays a role in the EE BTBR phenotype. PMID:36893171
At the same time points, samples were taken from the hypothalamus and hippocampus to monitor the expression of Ntrk2, Crh, and Pomc using real time PCR. PMID:36352380
Expression of plasticity genes Nr3c1, Creb1, Ntrk2; m6A modifying enzymes Fto, methyltransferase like (Mettl) 3 and 14; DNA methylation enzymes Dnmt1, Dnmt3a; transcription factor C/ebp α; and miRNA 124 3p were determined by quantitative polymerase chain reaction (qPCR) in the hippocampus of rats that showed susceptibility to develop stress induced depression (learned helplessness). PMID:36161325
Hippocampus of learned helplessness rats showed downregulation of Nr3c1, Creb1, and Ntrk2 along with enrichment in their m6A methylation. PMID:36161325
Namely, specific deletion of Ntrk2/Trkb from immature mouse hippocampal dentate granule cells (DGCs) affects their integration and maturation in the hippocampal circuitry and reduces Nkcc1 expression in their target region, the CA3 principal cells, leading to premature GABA shift, ultimately influencing the establishment of functional hippocampal circuitry and animal behaviour in adulthood. PMID:35448033
Namely, specific deletion of Ntrk2/Trkb from immature mouse hippocampal dentate granule cells (DGCs) affects their integration and maturation in the hippocampal circuitry and reduces Nkcc1 expression in their target region, the CA3 principal cells, leading to premature GABA shift, ultimately influencing the establishment of functional hippocampal circuitry and animal behaviour in adulthood. PMID:35448033
EXD exerts anti LOD effect by regulating the proteins related to neurogenesis in CSF, such as GDF11, NrCAM, NTRK2, and GhR and maintaining hippocampal neurogenesis. PMID:34951250
We found that expression of Ntrk3 and Ngfr was upregulated in the cortex and the hippocampus 1 3 hours after the seizures, while Ntrk2 expression increased after 3 6 hours in the anterior cortex and after 1 and 6 hours in the hippocampus. PMID:34903157
Mechanistically, XYW induced marked upregulation of mRNA and protein expression levels of NFE2L2, KEAP1, GPX3, HMOX1, SOD1, NQO1, OGG1, PIK3CA, p AKT1/AKT1, NTRK2, and BDNF, and downregulation of ROS in the cortex and hippocampus via the activation of the NFE2L2/KEAP1, PIK3CA/AKT1, and NTRK2/BDNF pathways. PMID:33935736
In the dentate gyrus, Bdnf, Ntrk2, and Chrna7 gene expression were upregulated and numbers of hilar TrkB[+] interneurons increased at weaning. PMID:33862172
Proteomic analysis followed by validation of western blot analysis revealed that several proteins in the MAPK pathway, such as NTRK2, AKT, and phospho ERK1/2, cPLA2 were significantly upregulated in the hippocampus of Prdx6[ / ] mice during the retrieval stage of contextual fear memory. PMID:33632301
This study quantified the gene expression of brain derived neurotrophic factor (BDNF), neurothrophin 4, tyrosine kinase receptor B (TrkB/NTRK2), insulin like growth factor (IGF 1), and insulin like growth factor receptor (IGF 1r) in the different areas of mother's brain (hypothalamus, hippocampus, and cortex), placenta, and fetus' brain of rats. PMID:32799949
Dams submitted to a LP diet during gestation showed upregulation of IGF 1r and BDNF messenger RNA in the hypothalamus, IGF 1r and NTRK2 in the hippocampus, and BDNF, NTRK2, IGF 1 and IGF 1r in the cortex. PMID:32799949
Voluntary physical activity attenuated the effects of LP diet on IGF 1r in the hypothalamus, IGF 1r and NTRK2 in the hippocampus, IGF 1 in the placenta, and NTRK2 in the fetus' brain. PMID:32799949
Immature Dentate Granule Cells Require Ntrk2/Trkb for the Formation of Functional Hippocampal Circuitry. PMID:32361506
Here, we show that early deletion of Ntrk2/Trkb from immature mouse hippocampal dentate granule cells (DGCs) affects the integration and maturation of newly formed DGCs in the hippocampal circuitry and drives a premature shift from depolarizing to hyperpolarizing GABAergic actions in the target of DGCs, the CA3 principal cells of the hippocampus, by reducing the expression of the cation chloride importer Nkcc1. PMID:32361506
Here, we show that early deletion of Ntrk2/Trkb from immature mouse hippocampal dentate granule cells (DGCs) affects the integration and maturation of newly formed DGCs in the hippocampal circuitry and drives a premature shift from depolarizing to hyperpolarizing GABAergic actions in the target of DGCs, the CA3 principal cells of the hippocampus, by reducing the expression of the cation chloride importer Nkcc1. PMID:32361506
Here, we show that early deletion of Ntrk2/Trkb from immature mouse hippocampal dentate granule cells (DGCs) affects the integration and maturation of newly formed DGCs in the hippocampal circuitry and drives a premature shift from depolarizing to hyperpolarizing GABAergic actions in the target of DGCs, the CA3 principal cells of the hippocampus, by reducing the expression of the cation chloride importer Nkcc1. PMID:32361506
The mRNA expression levels of Avp, Pomc, Crh, Crhbp, Crhr1, Bdnf, Ntrk2, Maoa, Maob, and Comt were assessed in the hippocampus and frontal cortex of 5 htt[±] and 5 htt[+/+] male and female adult rats exposed, or not, to daily maternal separation for 180 min during the first 2 postnatal weeks. PMID:30614673
In contrast, number of hilar SST[+] interneurons increased and Bdnf and Ntrk2 transcripts upregulated in the dentate gyrus, suggesting a facilitation of BDNF TRKB signaling for progenitor cell proliferation. PMID:30071239
Measurements for expression of caspase 3 by immunohistochemistry, cleavage of poly adenosine diphosphate ribose polymerase (PARP) by western blotting, as well as levels of brain derived neurotrophic factor (BDNF), tyrosine kinase receptor type 2 (Ntrk2), pro BDNF, p75 neurotrophin receptor (p75NTR) and protein kinase B (PKB/Akt) by enzyme linked immunosorbent assay were performed in the hippocampus of 12 mice from each group. PMID:29731813
Since sex specific endocrine mechanisms respond to environmental stimulus by altering the neuronal epigenome, we examined the genome wide profile of hippocampal 5hmC in female mice following exposure to acute stress and identified 363 differentially hydroxymethylated regions (DhMRs) linked to known (e.g., Nr3c1 and Ntrk2) and potentially novel genes associated with stress response and psychiatric disorders. PMID:27576189
The chronic consumption of a high fat diet decreased the hippocampal gene expression levels of mammalian target of rapamycin (mTOR), neurotrophic tyrosine kinase receptor type 2 (NTRK2) and synaptophysin. PMID:25760229
These data highlighted the importance of intact GIPR signalling and dietary composition in modulating memory and learning, and hippocampal pathways involved in the maintenance of synaptic plasticity, including mTOR and NTRK2, appear to be key in this regard. PMID:25760229
Lixisenatide improved recognition memory during a novel object recognition task and this was associated with up regulation of hippocampal expression of neurotrophic tyrosine kinase receptor type 2 (NTRK2) and mammalian target of rapamycin (mTOR) genes involved in modulating synaptic plasticity and long term potentiation. PMID:25195184
Expression of fundamental hippocampal genes including mTOR, VEGF, NTRK2 and SIRT1 was also increased significantly (p < 0.001) by all treatments. PMID:24998752
The receptor tyrosine kinase TrkB (also known as NTRK2), known primarily for its function during PNS and CNS development, has emerged in recent years as a potent regulator of hippocampal LTP. PMID:19927149