CAMK2G and signalling

    44 sentences in 31 studies


  1. Compared to si NT, transfection with si CAMK2G and si CAMK2D both significantly inhibited the expressions of PI3K/Akt/Erk signaling pathway components (P < 0.01). PMID:38597448
  2. To address this, we screened for PEAK1 effectors by affinity purification and mass spectrometry, identifying calcium/calmodulin dependent protein kinase 2 (CAMK2)D and CAMK2G. PMID:38405732
  3. The calcium/calmodulin dependent protein kinase type 2 (CAMK2) family consists of four different isozymes, encoded by four different genes CAMK2A, CAMK2B, CAMK2G, and CAMK2D of which the first three have been associated recently with neurodevelopmental disorders. PMID:38272033
  4. DEGs were identified mainly in the striatum and were associated with synaptic transmission (e.g., Grm2, Dlgap1), G protein signaling pathways (e.g., Gnal, Prkcg1, and Camk2g), as well as excitation/inhibition balance (e.g., Gad2). PMID:37008785
  5. The gamma subunit of calcium/calmodulin dependent protein kinase 2 (CAMK2G) is expressed throughout the brain and is associated with neurodevelopmental disorders. PMID:36685241
  6. Furthermore, we find that the calcium dependent protein kinase Camk2g is required downstream of Pkd function to repress klf2a expression. PMID:36639367
  7. Phosphorylation of JIP4 at T217 by CaMK2G in response to Ca[2+] fluxes tightly regulated this system. PMID:36394115
  8. Thus, the camk2g/miR 21 3p/lncRNA/circRNA network, CXCL10/CXCR3, and IL 17 signaling pathways might provide novel insights and targets for further studying the lung injury mechanism and clinical treatment. PMID:36246560
  9. Conditional cluster analysis revealed several genes (SOCS6, SOCS6.1, ARAF, CAMK2G, GNA1C, ITGA2, PRKACA, PTEN) that are involved in immune mediated signaling pathway had a distinct pattern of expression in the poly I:C treated organoids. PMID:35723330
  10. These include three genes (GNB2, ITPR1, and PLCB2) for the glutamatergic synapse pathway, six genes (P2RX6, EDNRB, GHR, GRID2, TSPO, and S1PR1) for neuroactive ligand receptor interaction, eight genes (CAMK2G, MAP2K1, RAF1, PDE3A, RRAS2, VAV1, ATP1B2, and GLI3) for the cAMP signaling pathway, and four genes (GNB2, CAMK2G, ITPR1, and PLCB2) for the dopaminergic synapse pathway. PMID:35386517
  11. These include three genes (GNB2, ITPR1, and PLCB2) for the glutamatergic synapse pathway, six genes (P2RX6, EDNRB, GHR, GRID2, TSPO, and S1PR1) for neuroactive ligand receptor interaction, eight genes (CAMK2G, MAP2K1, RAF1, PDE3A, RRAS2, VAV1, ATP1B2, and GLI3) for the cAMP signaling pathway, and four genes (GNB2, CAMK2G, ITPR1, and PLCB2) for the dopaminergic synapse pathway. PMID:35386517
  12. ROS regulated phosphorylation of ITPKB by CAMK2G drives cisplatin resistance in ovarian cancer. PMID:35039634
  13. Through a high throughput synthetical lethal screening for clinically relevant targets using 290 kinase inhibitors, we identify calcium/calmodulin dependent protein kinase II gamma (CAMK2G) as a critical vulnerability in cisplatin resistant ovarian cancer cells. PMID:35039634
  14. Mechanistically, CAMK2G directly senses ROS, both basal and cisplatin induced, to control the phosphorylation of ITPKB at serine 174, which directly regulates ITPKB activity to modulate cisplatin induced ROS stress. PMID:35039634
  15. This study reveals a key kinase network consisting of CAMK2G and ITPKB for ROS sense and scavenging in ovarian cancer cells to maintain redox homeostasis, offering a potential strategy for cisplatin resistance treatment. PMID:35039634
  16. We investigated the molecular mechanisms underlying the therapeutic effect of CAMK2G inhibition and found that CAMK2G is activated by MPL signaling in MF model cells and is an effector in the MPL JAK2 signaling pathway in these cells. PMID:34521112
  17. Moreover, while comparing isogenic CRISPR Cas9 corrected versus non corrected DM1 cardiomyocytes, a prominent difference in the splicing pattern for a number of candidate genes was apparent pertaining to genes that are associated with cardiac function (TNNT, TNNT2, TTN, TPM1, SYNE1, CACNA1A, MTMR1, NEBL, TPM1), cellular signaling (NCOR2, CLIP1, LRRFIP2, CLASP1, CAMK2G), and other DM1 related genes (i.e., NUMA1, MBNL2, LDB3) in addition to the disease causing DMPK gene itself. PMID:34371182
  18. Interestingly, calcium/calmodulin dependent protein kinase II, gamma (CAMK2G) was alternatively spliced in both settings, with variant 1 (v1) substantially decreased compared to variants 2 (v2) and 3 (v3). PMID:34162925
  19. Chromatin immunoprecipitation analysis of HIF1 in post MI hearts also demonstrated direct HIF1 binding to CAMK2G. PMID:34162925
  20. We studied GABA receptor functions by examining GABA receptor mediated calcium/calmodulin dependent kinase signaling genes (Calm1, Calm2, Calm3, Camk2a, Camk2b, Camk2g, Camk2d, Camk4) in the testosterone induced impulsivity model. PMID:33240041
  21. We studied GABA receptor functions by examining GABA receptor mediated calcium/calmodulin dependent kinase signaling genes (Calm1, Calm2, Calm3, Camk2a, Camk2b, Camk2g, Camk2d, Camk4) in the testosterone induced impulsivity model. PMID:33240041
  22. Additionally, CD40, F11R, TNRC18, and calcium/calmodulin dependent protein kinase type II gamma (CAMK2G) were screened out and validated using enzyme linked immunosorbent assay (ELISA) in an independent patient cohort and immunohistochemical (IHC) staining in an atherosclerosis mouse model. PMID:32714363
  23. Human dermal microvascular endothelial cells and human primary skin fibroblasts were stimulated with dSSc neutrophils EXOs, these fibrosis related genes were detected and some changes were found, such as ENST00000533886.1 hsa miR 1268a CAMK2G in Wnt and IL 23 signaling pathways, ENST00000610091.1 hsa miR 299 3p, 512 3p CPT1A in IL 23 and AMPK signaling pathways, NR_001564.2, ENST00000520562.1, ENST00000596567.1 hsa miR 299 3p, 512 3p TFDP2 in IL 23, AMPK and NOTCH signaling pathways. PMID:32147195
  24. Then we treated rats with propylthiouracil (PTU), T3, streptozotocin (STZ), and Ang II and evaluated the impact of these hormones on the splicing of titin, LIM domain binding 3 (Ldb3), calcium/calmodulin dependent protein kinase II gamma (Camk2g), and triadin (Trdn). PMID:31614708
  25. Then we treated rats with propylthiouracil (PTU), T3, streptozotocin (STZ), and Ang II and evaluated the impact of these hormones on the splicing of titin, LIM domain binding 3 (Ldb3), calcium/calmodulin dependent protein kinase II gamma (Camk2g), and triadin (Trdn). PMID:31614708
  26. We further determined the mRNA levels of ryanodine receptors (RyR2; ARVC2), phospholamban (PLB or PLN), SR Ca[2+] pump (SERCA2; ATP2A1), an accessory protein FKBP12 (PPIASE), protein kinase A (PPNAD4), and Ca[2+]/calmodulin dependent protein kinase II (CAMK2G). PMID:31520233
  27. We additionally identify regulation of the phosphorylation of several calcium and calmodulin dependent protein kinases (CAMKs), including 2 sites of CAMK type II γ (CAMK2G), a protein known to regulate apoptosis. PMID:31199885
  28. We additionally identify regulation of the phosphorylation of several calcium and calmodulin dependent protein kinases (CAMKs), including 2 sites of CAMK type II γ (CAMK2G), a protein known to regulate apoptosis. PMID:31199885
  29. In conclusion, we establish NKA as the coordinator of a broad, tightly regulated phosphorylation response in cells and define CAMK2G as a downstream effector of NKA. PMID:31199885
  30. Conversely, the lack of extinction training (sham extinction) upregulated genes associated with kinases (Camk2g), neurotrophins (Ngfr), synaptic connectivity factors (Ephb2), glutamate neurotransmission (Grm8) and opioid receptors (μ1, Δ1). PMID:31173919
  31. Eight genes [(GTPase NRas (NRAS), calcium/calmodulin‑dependent protein kinase type II subunit Gamma (CAMK2G), platelet‑derived growth factor receptor alpha (PDGFRA), calmodulin 3 (CALM3), cyclin‑dependent kinase 6 (CDK6), calcium/calmodulin‑dependent protein kinase type II subunit beta (CAMK2B), retinoblastoma‑associated protein (RB1) and protein kinase C beta type (PRKCB)] that were centralized in the glioma pathway were selected for CMap analysis. PMID:30816530
  32. The Calcium Calmodulin Dependent Protein Kinase II alpha (CAMK2A) and gamma (CAMK2G) were identified as potential targets. PMID:30231506
  33. The molecular dynamics simulation carried out here have demonstrated that aconitine alkaloids possess binding stability for the receptor CAMK2G. PMID:30231506
  34. Five novel in frame fusion transcripts were identified and verified in 40 EACs and in a validation cohort of 15 additional EACs (55 patients in all): fibroblast growth factor receptor 2 (FGFR2) GRB2 associated binding protein 2 (GAB2) in 2 of 55 or 3.6%, Niemann Pick C1 (NPC1) maternal embryonic leucine zipper kinase (MELK) in 2 of 55 or 3.6%, ubiquitin specific peptidase 54 (USP54) calcium/calmodulin dependent protein kinase II γ (CAMK2G) in 2 of 55 or 3.6%, megakaryoblastic leukemia (translocation) 1 (MKL1) fibulin 1 (FBLN1) in 1 of 55 or 1.8%, and CCR4 NOT transcription complex subunit 2 (CNOT2) chromosome 12 open reading frame 49 (C12orf49) in 1 of 55 or 1.8%. PMID:28640357
  35. Five novel in frame fusion transcripts were identified and verified in 40 EACs and in a validation cohort of 15 additional EACs (55 patients in all): fibroblast growth factor receptor 2 (FGFR2) GRB2 associated binding protein 2 (GAB2) in 2 of 55 or 3.6%, Niemann Pick C1 (NPC1) maternal embryonic leucine zipper kinase (MELK) in 2 of 55 or 3.6%, ubiquitin specific peptidase 54 (USP54) calcium/calmodulin dependent protein kinase II γ (CAMK2G) in 2 of 55 or 3.6%, megakaryoblastic leukemia (translocation) 1 (MKL1) fibulin 1 (FBLN1) in 1 of 55 or 1.8%, and CCR4 NOT transcription complex subunit 2 (CNOT2) chromosome 12 open reading frame 49 (C12orf49) in 1 of 55 or 1.8%. PMID:28640357
  36. Two patients had activating mutations in key signaling pathways (STAT5B (p.N642H) and CAMK2G (p.T306M)). PMID:25800665
  37. Simultaneously, VLX activated the expression of genes involved in neurotrophic signaling (Ntrk2, Ntrk3), glutamatergic transmission (Gria3, Grin2b and Grin2a), neuroplasticity (Camk2g/b, Cd47), synaptogenesis (Epha5a, Gad2) and cognitive processes (Clstn2). PMID:25423262
  38. Using exogenous expression of different cRNAs in Camk2g( / ) eggs, we show that the other multifunctional CaM kinases, CaMKI, and CaMKIV, are not capable of substituting CaMKIIγ to initiate cell cycle resumption in response to a rise in intracellular Ca (2+). PMID:24626179
  39. We show that exogenous expression of either Camk2g, Camk2d, or ca Camk4, but not Camk1, Camk4, or a catalytically inactive mutant form of CaMKIIγ (kinase dead) in Camk2g( / ) mouse eggs leads to almost complete degradation (~90%) of exogenously expressed EMI2 followed by cell cycle resumption. PMID:24626179
  40. The most significant pathways are related to post NMDA receptor activation events, driven by genetic variants in calcium/calmodulin dependent protein kinase II (CAMK2G, CAMK2D) and a calcium regulated nucleotide exchange factor (RASGRF2) in which all are activated by intracellular calcium/calmodulin. PMID:23274185
  41. Finally, bosutinib is the first kinase inhibitor shown to target CAMK2G, recently implicated in myeloid leukemia cell proliferation. PMID:19039322
  42. The cell cycle progression was down regulated, in which several genes were validated involved, including the cell cycle regulators (CDK6, STK6, CENPA, and CCNF), the transcription factor ID 1, and the calcium signaling molecules (CAMK2G and NFAT5). PMID:18644392
  43. Human calcium/calmodulin dependent protein kinase II gamma gene (CAMK2G): cloning, genomic structure and detection of variants in subjects with type II diabetes. PMID:12032636
  44. Human CAMK2G was cloned from a total human P1 artificial chromosome library using a partial Ca(2+)/calmodulin dependent protein kinase gamma(E) cDNA probe. PMID:12032636